2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Zuclomiphene

Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease.

For research use only. We do not sell to patients.

Zuclomiphene

Zuclomiphene Chemical Structure

CAS No. : 15690-55-8

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Zuclomiphene Related Antibodies

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Description

Zuclomiphene is a cis isomer of Clomiphene citrate (HY-B0463). Zuclomiphene is orally active and has an antiestrogenic effect. Zuclomiphene can reduce cholesterol levels. Zuclomiphene can be for the researches of endocrinology and metabolic disease[1][2].

Cellular Effect
Cell Line Type Value Description References
HT-1080 IC50
37.86 μM
Compound: 76
Inhibition of IDH1 R132H mutant in human HT-1080 cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysis
Inhibition of IDH1 R132H mutant in human HT-1080 cells assessed as suppression of 2-HG production incubated for 48 hrs by LC-MS analysis
[PMID: 29847930]
In Vivo

Zuclomiphene (4-40 mg/kg, i.g., daily for 90 days ) reduces testes Rweight in male mice[1].
Zuclomiphene (30 mg/kg, i.p., twice a week) reduces cholesterol content in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice[1]
Dosage: 4 and 40 mg/kg
Administration: Orally gavage
Result: Reduced leydig cells surrounding the tubules in size and numbers.
Showed testicular degeneration and an absence of sperm in the seminiferous tubules.
Reduced kidney weights and body weight.
Reduced levels of LH, FSH and testosterone.
Molecular Weight

405.96

Formula

C26H28ClNO
CAS No.
SMILES

Cl/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(CC)CC)C=C2)/C3=CC=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Zuclomiphene Related Classifications

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zuclomiphene15690-55-8Estrogen Receptor/ERRAntiestrogenicCholesterolERREndocrinologyMetabolicInhibitorinhibitorinhibit

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