2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Fumiporexant

Fumiporexant (Compound Example 93) is an orally active, brain-penetrant and selective Orexin receptor 2 (OX2R) antagonist. Fumiporexant regulates the sleep-wake cycle and emotion-related pathways in the central nervous system. Fumiporexant is promising for research of nervous system diseases such as insomnia and major depressive disorder.

For research use only. We do not sell to patients.

Fumiporexant Chemical Structure

Fumiporexant Chemical Structure

CAS No. : 2839408-03-4

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Fumiporexant Related Antibodies

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OX2 Receptor OX1 Receptor

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Description

Fumiporexant (Compound Example 93) is an orally active, brain-penetrant and selective Orexin receptor 2 (OX2R) antagonist. Fumiporexant regulates the sleep-wake cycle and emotion-related pathways in the central nervous system. Fumiporexant is promising for research of nervous system diseases such as insomnia and major depressive disorder[1].

IC50 & Target

OX2 Receptor

 

Molecular Weight

466.48

Formula

C24H24F2N6O2
CAS No.
SMILES

O=C(N1C[C@]2([H])[C@](CN(C3=NC=C(F)C(C(C)(O)C)=N3)C2)([H])C1)C4=C(C5=NC=CC=N5)C=CC=C4F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Fumiporexant Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fumiporexant2839408-03-4Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT Receptororally activebrain-penetrantOX2Rcentral nervous systemInhibitorinhibitorinhibit

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