Hexoprenaline 

Hexoprenaline is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline can dilate the bronchi. Hexoprenaline can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline exhibits anti-infection and anti-inflammmation effect. Hexoprenaline can increase placental weight and blood flow. Hexoprenaline can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds^{[1][2][3][4][5]}.

Hexoprenaline (10 nM-1 mM) activates adenylate cyclase in isolated rat gastric mucosal cells^[2].
Hexoprenaline (10-10000 nM) increasingly stimulate 14C-Aminopyrine uptake in isolated rat gastric mucosal cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hexoprenaline (sulfate) (1.5 mg/kg, s.c.) significantly reduces mortality and decreases plasma proinflammatory cytokine concentrations in mice with E. coli O157:H7-induced sepsis^[4].
Hexoprenaline (0.5 mg diet, p.o., daily) increases placental weight and blood flow in blood flow^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

420.50

C₂₂H₃₂N₂O₆

3215-70-1

Solid

Light brown to brown

OC(CNCCCCCCNCC(O)C1=CC=C(C(O)=C1)O)C2=CC=C(C(O)=C2)O

Room temperature in continental US; may vary elsewhere.

• [1]. Schonell M, et al. Bronchodilator effect of hexoprenaline aerosol in bronchial asthma and chronic bronchitis. Med J Aust. 1977 Dec 17;2(25):828-30.  [Content Brief]

  [2]. Ruoff HJ, et al. Adrenergic stimulation of isolated rat gastric mucosal cells. Effect on adenylate cyclase and 14C-aminopyrine uptake. Naunyn Schmiedebergs Arch Pharmacol. 1982 Aug;320(2):175-81.  [Content Brief]

  [3]. Zabrodskii P F. et al. The Mechanisms of the Cholinergic Anti-Inflammatory Pathway after Acute Intoxication of Organophosphorus Compounds[J]. Biomedical Journal, 2010, 1: 5.

  [4]. Zabrodskii P F. et al. The influence of various drugs on mortality of mice and the concentration of proinflammatory cytokines in blood at sepsis caused by E. coli[J]. Acta scientific microbiology, 2018, 1: 11-14.

  [5]. Lipshitz J, et al. Effect of long-term administration of beta 2-sympathomimetic drug in the diet-restricted pregnant rat model. Am J Obstet Gynecol. 1986 Feb;154(2):314-7.  [Content Brief]