TrkB activator-1 

TrkB activator-1 is a specific, orally active and brain-penetrant tropomyosin receptor kinase B (TrkB) activator. TrkB activator-1 shows potent antidepressant effects through activation of the activates the BDNF (brainderived neurotrophic factor)-Tropomyosin-related kinase B (TrkB)-CREB (cAMP response element binding protein) signaling aixs. TrkB activator-1 increaes neuroplasticity. TrkB activator-1 can be used for the research of neurological disease, such as depression^[1].

TrkB activator-1 (Compound B11) (3-100 100 μM, 24 h) increases the neurite total length, total count, and cross point count of hippocampal neurons^[1].
TrkB activator-1 (1-100 100 μM, 0.25-2 h) upregulates BDNF in a dose-dependent manner in hippocampal neurons^[1].
TrkB activator-1 (3-100 100 μM, 15 mins) increases the levels of p-TrkB, p-PLCγ, PKA and p-CREB in hippocampal neurons^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TrkB activator-1 (Compound B11) (7.5-100 mg/kg, p.o., a single dose) induces a rapid-acting antidepressant effect in the chronic unpredictable mild stress (CUMS) mice models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

268.33

C₁₃H₁₆D₃N₃O₃

3087336-56-6

O=C(N[C@H](C1=NC=CO1)C(C)C)[C@H]2CCN2C(C([2H])([2H])[2H])=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Cheng X, et al. Discovery of Rapid-Acting, Orally Available Antidepressants by Activating TrkB Signaling. J Med Chem. 2025 Aug 14;68(15):16781-16801.  [Content Brief]