2. GPCR/G Protein
  3. LPL Receptor
  4. ACT-1016-0707

ACT-1016-0707  (Synonyms: LPA1 receptor antagonist 2)

Cat. No.: HY-138453 Purity: 98.28%
COA
SDS
Handling Instructions Technical Support

ACT-1016-0707 (Compound 49) is an orally active and selective LPA1 receptor antagonist. ACT-1016-0707 can be used for the research of fibrotic diseases.

For research use only. We do not sell to patients.

ACT-1016-0707 Chemical Structure

ACT-1016-0707 Chemical Structure

CAS No. : 2569467-78-1

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Based on 1 publication(s) in Google Scholar

ACT-1016-0707 Related Antibodies

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Description

ACT-1016-0707 (Compound 49) is an orally active and selective LPA1 receptor antagonist. ACT-1016-0707 can be used for the research of fibrotic diseases[1].

Molecular Weight

438.93

Formula

C19H23ClN4O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1(C2=CC=CC=C2C(C)C)CN(S(=O)(N)=O)C1)NC3=C(OC)C=C(Cl)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (227.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2783 mL 11.3913 mL 22.7827 mL
5 mM 0.4557 mL 2.2783 mL 4.5565 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.28%

SDS (251 KB)

COA (256 KB) HNMR (281 KB) LCMS (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2783 mL 11.3913 mL 22.7827 mL 56.9567 mL
5 mM 0.4557 mL 2.2783 mL 4.5565 mL 11.3913 mL
10 mM 0.2278 mL 1.1391 mL 2.2783 mL 5.6957 mL
15 mM 0.1519 mL 0.7594 mL 1.5188 mL 3.7971 mL
20 mM 0.1139 mL 0.5696 mL 1.1391 mL 2.8478 mL
25 mM 0.0911 mL 0.4557 mL 0.9113 mL 2.2783 mL
30 mM 0.0759 mL 0.3797 mL 0.7594 mL 1.8986 mL
40 mM 0.0570 mL 0.2848 mL 0.5696 mL 1.4239 mL
50 mM 0.0456 mL 0.2278 mL 0.4557 mL 1.1391 mL
60 mM 0.0380 mL 0.1899 mL 0.3797 mL 0.9493 mL
80 mM 0.0285 mL 0.1424 mL 0.2848 mL 0.7120 mL
100 mM 0.0228 mL 0.1139 mL 0.2278 mL 0.5696 mL
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ACT-1016-0707 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ACT-1016-07072569467-78-1LPA1 receptor antagonist 2LPL ReceptorLysophospholipid Receptorfibrotic diseasesorally activeInhibitorinhibitorinhibit

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