2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Zandatrigine

Zandatrigine  (Synonyms: NBI-921352; XEN901)

Cat. No.: HY-147423 Purity: 99.28%
COA
SDS
Handling Instructions Technical Support

Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel NaV1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of NaV1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as NaV1.1 and NaV1.2, and has minimal effect on NaV1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study NaV1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy.

For research use only. We do not sell to patients.

Zandatrigine Chemical Structure

Zandatrigine Chemical Structure

CAS No. : 2154406-04-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Zandatrigine:

Zandatrigine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Zandatrigine

View All Sodium Channel Isoform Specific Products:

View All Isoforms
Nav1.1 Nav1.2 Nav1.3 Nav1.4 Nav1.5 Nav1.6 Nav1.7 Nav1.8 Nav1.9

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Zandatrigine (NBI-921352; XEN901) is a selective, orally active, voltage-gated sodium channel NaV1.6/SCN8A inhibitor that can penetrate the blood-brain barrier. Zandatrigine inhibits sodium influx by non-covalently binding to the VSD4 structure of NaV1.6, blocking the persistent and resuscitative currents under pathological conditions. Zandatrigine can reduce neuronal hyperexcitability and reduce epileptic seizures. Zandatrigine is 134-756-fold selective for other isoforms such as NaV1.1 and NaV1.2, and has minimal effect on NaV1.1 expressed by inhibitory interneurons. Zandatrigine can be used to study NaV1.6-mediated neuroexcitability diseases such as SCN8A-related developmental epileptic encephalopathy (SCN8A-DEE) and adult focal epilepsy[1][2].

IC50 & Target

NaV1.6/SCN8A

 

In Vitro

Zandatrigine significantly inhibits persistent sodium current (INaP) in HEK293 cells expressing NaV1.6, with IC50 of 0.051 μM and 0.058 μM for hNaV1.6 and mNaV1.6, respectively; while the IC50 for hNaV1.1, hNaV1.2, mNaV1.1, and NaV1.2 are 39 μM, 6.9 μM, 709 μM, and 191 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Zandatrigine Related Antibodies
In Vivo

Zandatrigine (15 mg/kg; oral; single dose, 2 hours before electrical epilepsy induction) significantly reduces the incidence of electric shock-induced generalized tonic-clonic seizures (GTCs) in the Scn8aN1768D/+ gene mutant mouse model, with an ED50 of 15 mg/kg, with a positively correlated concentration in the brain with the therapeutic effect[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Scn8aN1768D/+ mice (C57BL/6 background, F7 spring, 35-42 days old) with genetic epilepsy[1]
Dosage: 15 mg/kg, 10 mL/kg
Administration: Oral gavage, daily for 3 weeks
Result: Significantly reduced GTC seizures induced by electrical stimulation.
Showed the brain EC50 of 0.064 μM.
Clinical Trial
Molecular Weight

460.59

Formula

C22H25FN4O2S2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

CN([C@@H]1CN(CC1)CC2=CC=CC=C2)C3=C(C=C(C(F)=C3)S(NC4=CSC=N4)(=O)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (271.39 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1711 mL 10.8556 mL 21.7113 mL
5 mM 0.4342 mL 2.1711 mL 4.3423 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.28%

SDS (252 KB)

COA (249 KB) HNMR (288 KB) LCMS (88 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1711 mL 10.8556 mL 21.7113 mL 54.2782 mL
5 mM 0.4342 mL 2.1711 mL 4.3423 mL 10.8556 mL
10 mM 0.2171 mL 1.0856 mL 2.1711 mL 5.4278 mL
15 mM 0.1447 mL 0.7237 mL 1.4474 mL 3.6185 mL
20 mM 0.1086 mL 0.5428 mL 1.0856 mL 2.7139 mL
25 mM 0.0868 mL 0.4342 mL 0.8685 mL 2.1711 mL
30 mM 0.0724 mL 0.3619 mL 0.7237 mL 1.8093 mL
40 mM 0.0543 mL 0.2714 mL 0.5428 mL 1.3570 mL
50 mM 0.0434 mL 0.2171 mL 0.4342 mL 1.0856 mL
60 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9046 mL
80 mM 0.0271 mL 0.1357 mL 0.2714 mL 0.6785 mL
100 mM 0.0217 mL 0.1086 mL 0.2171 mL 0.5428 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Zandatrigine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zandatrigine2154406-04-7NBI-921352 XEN901NBI921352NBI 921352XEN901XEN 901XEN-901Sodium ChannelNa channelsNa+ channelsScn8αsodium channel protein type 8 subunit alphaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Zandatrigine
Cat. No.:
HY-147423
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (252 KB) Français - FR (252 KB) Deutsch - DE (252 KB) Norwegian - NO (252 KB) Español - ES (252 KB) Swedish - SV (252 KB) Italian - IT (252 KB) Portuguese - PT (252 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.