2. Apoptosis
  3. Apoptosis
  4. Clodronic acid

Clodronic acid  (Synonyms: Clodronate)

Cat. No.: HY-B0657 Purity: 99.41%
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Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density.

For research use only. We do not sell to patients.

Clodronic acid Chemical Structure

Clodronic acid Chemical Structure

CAS No. : 10596-23-3

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Based on 4 publication(s) in Google Scholar

Other Forms of Clodronic acid:

Clodronic acid Related Antibodies

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Description

Clodronic acid is an orally active bisphosphonate, which is used for researching osteoporosis and diseases associated with excessive bone resorption. Clodronic acid inhibits bone resorption through induction of osteoclast apoptosis. Clodronic acid is effective in the maintenance or improvement of bone mineral density[1].

Clinical Trial
Molecular Weight

244.89

Formula

CH4Cl2O6P2
CAS No.
Appearance

Solid-Liquid Mixture

Color

Colorless to light yellow

SMILES

ClC(P(O)(O)=O)(Cl)P(O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (510.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0835 mL 20.4173 mL 40.8347 mL
5 mM 0.8167 mL 4.0835 mL 8.1669 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0835 mL 20.4173 mL 40.8347 mL 102.0867 mL
5 mM 0.8167 mL 4.0835 mL 8.1669 mL 20.4173 mL
10 mM 0.4083 mL 2.0417 mL 4.0835 mL 10.2087 mL
15 mM 0.2722 mL 1.3612 mL 2.7223 mL 6.8058 mL
20 mM 0.2042 mL 1.0209 mL 2.0417 mL 5.1043 mL
25 mM 0.1633 mL 0.8167 mL 1.6334 mL 4.0835 mL
30 mM 0.1361 mL 0.6806 mL 1.3612 mL 3.4029 mL
40 mM 0.1021 mL 0.5104 mL 1.0209 mL 2.5522 mL
50 mM 0.0817 mL 0.4083 mL 0.8167 mL 2.0417 mL
60 mM 0.0681 mL 0.3403 mL 0.6806 mL 1.7014 mL
80 mM 0.0510 mL 0.2552 mL 0.5104 mL 1.2761 mL
100 mM 0.0408 mL 0.2042 mL 0.4083 mL 1.0209 mL
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Clodronic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clodronic acid10596-23-3ClodronateApoptosisbone resorptionosteoporosisbone mineral densityInhibitorinhibitorinhibit

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