2. Metabolic Enzyme/Protease Apoptosis
  3. Mitochondrial Metabolism Apoptosis
  4. Perhexiline maleate

Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina.

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Perhexiline maleate Chemical Structure

Perhexiline maleate Chemical Structure

CAS No. : 6724-53-4

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Solution
10 mM * 1 mL in Ethanol In-stock
Solid
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Based on 4 publication(s) in Google Scholar

Other Forms of Perhexiline maleate:

Perhexiline maleate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Perhexiline maleate is an orally active CPT1 and CPT2 inhibitor that reduces fatty acid metabolism. Perhexiline maleate induces mitochondrial dysfunction and apoptosis in hepatic cells. Perhexiline maleate can cross the blood brain barrier (BBB) and shows anti-tumor activity. Perhexiline maleate can be used in the research of cancers, and cardiovascular disease like angina[1][2][5].

IC50 & Target

IC50: 77 μM (Rat heart CPT 1), 148 μM (Rat liver CPT 1)[1]
In Vitro

Perhexiline (5-25 μM, 2-6 h) maleate reduces cell viability in HepG2 cells[2].
Perhexiline (5-25 μM, 2-6 h) maleate reduces cellular ATP content and Lactate dehydrogenase (LDH) release in HepG2 cells[2].
Perhexiline (20 μM, 2 h) maleate activates caspase 3/7 in HepG2 cells[2].
Perhexiline (5-25 μM, 4 h) maleate causes mitochondrial dysfunction in HepG2 cells[2].
Perhexiline (5 μM, 48 h) maleate selectively induces massive apoptosis in CLL cells (high expression of CPT)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Perhexiline maleate Related Antibodies

Cell Viability Assay[2]

Cell Line: HepG2 cells
Concentration: 5, 10, 15, 25 μM
Incubation Time: 2, 4, 6 h
Result: Induced time- and concentration-dependent cytotoxicity in hepatic cells.

Western Blot Analysis[2]

Cell Line: HepG2 cells
Concentration: 5, 10, 15, 25 μM
Incubation Time: 2 h
Result: Reduced Bcl-2 and Mcl-1 level, and increased Bad level.
In Vivo

Perhexiline (200 mg/kg, p.o., daily for 8 weeks) maleate reduces peripheral neural function in female DA rats[4].
Perhexiline (80 mg/kg, oral gavage, for 3 days) maleate demonstrates anti-tumor activity in glioblastoma mouse model[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Orthotopic glioblastoma mouse model[5]
Dosage: 80 mg/kg
Administration: Oral gavage, for 3 days.
Result: Reduces tumor size (MR imaging) and improves in overall survival.
Clinical Trial
Molecular Weight

393.56

Formula

C23H39NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C\C(O)=O.C1(CC(C2CCCCC2)C3CCCCC3)NCCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (42.36 mM; ultrasonic and adjust pH to 5 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5409 mL 12.7045 mL 25.4091 mL
5 mM 0.5082 mL 2.5409 mL 5.0818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 5 mg/mL (12.70 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.26%

SDS (393 KB)

COA (248 KB) LCMS (399 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5409 mL 12.7045 mL 25.4091 mL 63.5227 mL
5 mM 0.5082 mL 2.5409 mL 5.0818 mL 12.7045 mL
10 mM 0.2541 mL 1.2705 mL 2.5409 mL 6.3523 mL
15 mM 0.1694 mL 0.8470 mL 1.6939 mL 4.2348 mL
20 mM 0.1270 mL 0.6352 mL 1.2705 mL 3.1761 mL
25 mM 0.1016 mL 0.5082 mL 1.0164 mL 2.5409 mL
30 mM 0.0847 mL 0.4235 mL 0.8470 mL 2.1174 mL
40 mM 0.0635 mL 0.3176 mL 0.6352 mL 1.5881 mL
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Perhexiline maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perhexiline6724-53-4Mitochondrial MetabolismApoptosisAnti-anginalcancerglioblastomaBBBmitochondrial dysfunctionHepG2CLL cellInhibitorinhibitorinhibit

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