2. Others NF-κB Stem Cell/Wnt MAPK/ERK Pathway TGF-beta/Smad
  3. Reference Standards NF-κB ERK TGF-beta/Smad
  4. Fluorofenidone (Standard)

Fluorofenidone (Standard) is the analytical standard of Fluorofenidone (AKF-PD) (HY-121246). This product is intended for research and analytical applications. Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC).

For research use only. We do not sell to patients.

Fluorofenidone (Standard)

Fluorofenidone (Standard) Chemical Structure

CAS No. : 848353-85-5

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1 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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10 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
25 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
50 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
100 mg Get quote 5 - 7 weeks 4 - 6 weeks 4 - 6 weeks
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Information

Fluorofenidone (Standard) is the analytical standard of Fluorofenidone (AKF-PD) (HY-121246). This product is intended for research and analytical applications. Fluorofenidone is an orally active compound with anti-fibrotic, antioxidant, and anti-inflammatory pharmacological effects. Fluorofenidone downregulates the expression of ACSL4, upregulates GPX4 expression and inhibits the NF-κB signaling pathway to alleviate inflammation and fibrosis. Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice. Fluorofenidone demonstrates protective effects against chronic lung injury in mice. Fluorofenidone can be used for the study of chronic obstructive pulmonary disease (COPD), pulmonary interstitial fibrosis (PIF) and non-small cell lung cancer (NSCLC).

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

203.21

Formula

C12H10FNO
CAS No.
SMILES

O=C1C=CC(C)=CN1C2=CC=CC(F)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Fluorofenidone (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluorofenidone (Standard)848353-85-5Reference StandardsNF-κBERKTGF-beta/SmadNuclear factor-κBNuclear factor-kappaBExtracellular signal regulated kinasesTransforming growth factor betaanti-fibroticantioxidantanti-inflammatoryErk/-Egr-1Tgfβ1/SmadInhibitorinhibitorinhibit

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