Polydextrose 

Polydextrose is an orally active prebiotic. Polydextrose promotes the growth of Pediococcus pentosaceus ATCC 43200. Polydextrose reduces cholesterol and synergistically lowers blood sugar with Sitagliptin (HY-13749). Currently, it is mainly used in the research of diseases such as hyperlipidemia, type 2 diabetes, and postoperative iron deficiency anemia^{[1][2][3][4][5]}.

Polydextrose (0.5%-1.5%; 24 h; pH 6.0, 35℃, 50-150 rpm) significantly promotes the growth of Pediococcus pentosaceus ATCC 43200 in MRS medium and increases the lactic acid yield^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Polydextrose (6%; p.o. via diets; 3-4 weeks) significantly reduces plasma and liver cholesterol levels in cholesterol-fed gerbils with an expanded endogenous cholesterol pool, without significantly affecting body and organ weights^[1].
Polydextrose (7.5%; p.o. via diets; 60-day administration period) increases cecal SCFAs concentration (acetate by 198.4%), decreases cecal pH, and increases hemoglobin (29.2%) and hematocrit (55.8%) in rats undergoing partial gastrectomy (Billroth II procedure + vagotomy)^[4]
Polydextrose (0.25 g/day; p.o.; daily; 6 weeks) combined with Sitagliptin (HY-13749) significantly reduces the area under the curve of the oral glucose tolerance test (by 28%) and glycaemia in high-fat diet-induced diabetic mice, and increases portal vein GLP-1 concentration^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

C₁₂H₂₂O₁₁

68424-04-4

Solid

White to off-white

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Room temperature in continental US; may vary elsewhere.

• [1]. Pronczuk A, et al. Hypocholesterolemic effect of dietary polydextrose in gerbils and humans[J]. Nutrition Research, 2006, 26(1): 27-31.

  [2]. Mäkeläinen HS, et al. The effects of polydextrose and xylitol on microbial community and activity in a 4-stage colon simulator. J Food Sci. 2007 Jun;72(5):M153-9.  [Content Brief]

  [3]. Wanderley Porto MC, et al. Effect of Polydextrose on the Growth of Pediococcus pentosaceus as Well as Lactic Acid and Bacteriocin-like Inhibitory Substances (BLIS) Production. Microorganisms. 2022 Sep 24;10(10):1898.  [Content Brief]

  [4]. do Carmo MMR, et al. Intake of Polydextrose Alters Hematology and the Profile of Short Chain Fatty Acids in Partially Gastrectomized Rats. Nutrients. 2018 Jun 20;10(6):792.  [Content Brief]

  [5]. Stenman LK, et al. Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice. Diabetol Metab Syndr. 2015 Sep 12;7:75.  [Content Brief]