2. MAPK/ERK Pathway Stem Cell/Wnt
  3. ERK p38 MAPK
  4. ITZ-1

ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases.

For research use only. We do not sell to patients.

ITZ-1

ITZ-1 Chemical Structure

CAS No. : 1180532-17-5

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ITZ-1 Related Antibodies

Top Publications Citing Use of Products

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

ITZ-1 is an orally active and selective extracellular signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) pathway inhibitor with an IC50 of 0.51 μM for inhibiting interleukin-1β (IL-1β)-induced matrix metalloproteinase-13 (MMP-13) production. ITZ-1 reduces MMP-13 expression and suppresses nitric oxide (NO)-induced chondrocyte apoptosi. ITZ-1 is promising for research of osteoarticular diseases[1].

Molecular Weight

541.58

Formula

C20H20F5N3O3S3
CAS No.
SMILES

O=S(C1=CC=C(C)C=C1)(/N=C(C2=C(SCCCC(F)(F)C(F)(F)F)SC(C)=C(C)N23)\NC3=O)=O
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Purity & Documentation
References
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ITZ-1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ITZ-11180532-17-5ITZ1ITZ 1ERKp38 MAPKExtracellular signal regulated kinasesMAPKosteoarticular diseasesInhibitorinhibitorinhibit

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