2. Others Neuronal Signaling
  3. Cholinesterase (ChE) Isotope-Labeled Compounds
  4. (S)-Rivastigmine-d4

(S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

For research use only. We do not sell to patients.

(S)-Rivastigmine-d<sub>4</sub> Chemical Structure

(S)-Rivastigmine-d4 Chemical Structure

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Other Forms of (S)-Rivastigmine-d4:

(S)-Rivastigmine-d4 Related Antibodies

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Description

(S)-Rivastigmine-d4 is deuterium labeled Rivastigmine. Rivastigmine (ENA 713 free base) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM , 4.15 μM, respectively. Rivastigmine can pass the blood brain barrier (BBB). Rivastigmine is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2][3].

Molecular Weight

254.36

Formula

C14H18D4N2O2
Unlabeled CAS
SMILES

CCN(C(OC1=CC([C@@H](N(C([2H])([H])[2H])C([2H])([H])[2H])C)=CC=C1)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (196.57 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9314 mL 19.6572 mL 39.3144 mL
5 mM 0.7863 mL 3.9314 mL 7.8629 mL
View the Complete Stock Solution Preparation Table

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.9314 mL 19.6572 mL 39.3144 mL 98.2859 mL
5 mM 0.7863 mL 3.9314 mL 7.8629 mL 19.6572 mL
10 mM 0.3931 mL 1.9657 mL 3.9314 mL 9.8286 mL
15 mM 0.2621 mL 1.3105 mL 2.6210 mL 6.5524 mL
20 mM 0.1966 mL 0.9829 mL 1.9657 mL 4.9143 mL
25 mM 0.1573 mL 0.7863 mL 1.5726 mL 3.9314 mL
30 mM 0.1310 mL 0.6552 mL 1.3105 mL 3.2762 mL
40 mM 0.0983 mL 0.4914 mL 0.9829 mL 2.4571 mL
50 mM 0.0786 mL 0.3931 mL 0.7863 mL 1.9657 mL
60 mM 0.0655 mL 0.3276 mL 0.6552 mL 1.6381 mL
80 mM 0.0491 mL 0.2457 mL 0.4914 mL 1.2286 mL
100 mM 0.0393 mL 0.1966 mL 0.3931 mL 0.9829 mL
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(S)-Rivastigmine-d4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-Rivastigmine-d4Cholinesterase (ChE)Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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