2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Bromopride hydrochloride

Bromopride hydrochloride is a selective, irreversible, competitive, and orally active dopamine D2 receptor antagonist. Bromopride hydrochloride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride hydrochloride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride hydrochloride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting).

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Bromopride hydrochloride Chemical Structure

Bromopride hydrochloride Chemical Structure

CAS No. : 52423-56-0

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Bromopride hydrochloride Related Antibodies

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Description

Bromopride hydrochloride is a selective, irreversible, competitive, and orally active dopamine D2 receptor antagonist. Bromopride hydrochloride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride hydrochloride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride hydrochloride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting)[1][2].

IC50 & Target

D2 Receptor

 

In Vitro

Axon regeneration assay: Bromopride hydrochloride (100 μM; 5 d) significantly promotes axon regeneration in a rat cortical neuron scratch injury model and reversed the inhibitory effect of chondroitin sulfate proteoglycan (CSPG) on axon growth[1].
Metabolite analysis assay: Bromopride hydrochloride (10 μM; 4 h) can be metabolized into 20 metabolites in mouse, rat, rabbit, dog, monkey and human hepatocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromopride hydrochloride Related Antibodies

Cell Viability Assay[1]

Cell Line: Rat embryonic cortical neurons (21 DIV), mouse dorsal root ganglion (DRG) neurons
Concentration: 100 μM
Incubation Time: 5 days (cortical scrape); 24 hours (DRG)
Result: Increased axon regeneration into the lesion area by ~1.6-fold compared to CSPG-treated controls in rat cortical cultures wounded at 21 DIV, as quantified by βIII-tubulin immunostaining and image analysis.
Enhanced total axon length per neuron in adult mouse DRG neurons cultured on CSPG-coated plates, demonstrating its ability to counteract CSPG-mediated growth inhibition.
In Vivo

Rat sexual behavior model: Bromopride (20-60 mg; intravenous injection; single dose) hydrochloride dose-dependently inhibited male rat mating behavior (such as prolonged post-ejaculation latency) and increased serum prolactin levels[2].
Rat peritonitis model: Bromopride (1 mg/kg; subcutaneous injection; every 12 hours; 3/7 days) hydrochloride significantly reduced abdominal wall wound edema and fibrin deposition in Wistar rats with induced peritonitis 7 days after surgery, without affecting wound breaking strength[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (90-120 days, 350-575 g) with induced peritoneal sepsis via cecal ligation/perforation + left colon resection/anastomosis[3]
Dosage: 1 mg/kg Bromopride
Administration: Subcutaneous injection every 12 h until euthanasia (postoperative day 3 or 7)
Result: Reduced abdominal wall edema (p=0.041) and fibrin deposition (p=0.041) compared to controls (GC7) on day 7, with no significant difference in wound breaking strength. No adverse effects on survival or clinical signs (apathy, diarrhea) were observed.
Molecular Weight

380.71

Formula

C14H23BrClN3O2
CAS No.
SMILES

O=C(C1=CC(Br)=C(C=C1OC)N)NCCN(CC)CC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Bromopride hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromopride52423-56-0Dopamine ReceptorInhibitorinhibitorinhibit

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