2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Bromopride

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting).

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Bromopride Chemical Structure

Bromopride Chemical Structure

CAS No. : 4093-35-0

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Based on 1 publication(s) in Google Scholar

Other Forms of Bromopride:

Bromopride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Bromopride

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Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Bromopride is a selective, irreversible, competitive, and orally effective dopamine D2 receptor antagonist. Bromopride can pass through the blood-brain barrier, inhibit the vomiting center, and enhance gastrointestinal motility, exerting antiemetic and gastrointestinal motility effects. Bromopride antagonizes dopamine-mediated vomiting reflexes and promotes gastrointestinal smooth muscle contraction, and has no adverse effects on abdominal wall healing in rats with postoperative abdominal infection. Bromopride can be used for the study of digestive system diseases (such as gastric hypomotility, nausea and vomiting)[1][2].

IC50 & Target

D2 Receptor

 

In Vitro

Axon regeneration assay: Bromopride (100 μM; 5 d) significantly promotes axon regeneration in a rat cortical neuron scratch injury model and reversed the inhibitory effect of chondroitin sulfate proteoglycan (CSPG) on axon growth[1].
Metabolite analysis assay: Bromopride (10 μM; 4 h) can be metabolized into 20 metabolites in mouse, rat, rabbit, dog, monkey and human hepatocytes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromopride Related Antibodies

Cell Viability Assay[1]

Cell Line: Rat embryonic cortical neurons (21 DIV), mouse dorsal root ganglion (DRG) neurons
Concentration: 100 μM (cortical scrape assay); unspecified (DRG assay, inferred from context)
Incubation Time: 5 days (cortical scrape); 24 hours (DRG)
Result: Increased axon regeneration into the lesion area by ~1.6-fold compared to CSPG-treated controls in rat cortical cultures wounded at 21 DIV, as quantified by βIII-tubulin immunostaining and image analysis.
Enhanced total axon length per neuron in adult mouse DRG neurons cultured on CSPG-coated plates, demonstrating its ability to counteract CSPG-mediated growth inhibition.
In Vivo

Rat sexual behavior model: Bromopride (20-60 mg; intravenous injection; single dose) dose-dependently inhibited male rat mating behavior (such as prolonged post-ejaculation latency) and increased serum prolactin levels[2].
Rat peritonitis model: Bromopride (1 mg/kg; subcutaneous injection; every 12 hours; 3/7 days) significantly reduced abdominal wall wound edema and fibrin deposition in Wistar rats with induced peritonitis 7 days after surgery, without affecting wound breaking strength[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (90-120 days, 350-575 g) with induced peritoneal sepsis via cecal ligation/perforation + left colon resection/anastomosis[3]
Dosage: 1 mg/kg
Administration: Subcutaneous injection every 12 h until euthanasia (postoperative day 3 or 7)
Result: Rreduced abdominal wall edema (p=0.041) and fibrin deposition (p=0.041) compared to controls (GC7) on day 7, with no significant difference in wound breaking strength. No adverse effects on survival or clinical signs (apathy, diarrhea) were observed.
Clinical Trial
Molecular Weight

344.25

Formula

C14H22BrN3O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCN(CC)CC)C1=CC(Br)=C(N)C=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 170 mg/mL (493.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9049 mL 14.5243 mL 29.0487 mL
5 mM 0.5810 mL 2.9049 mL 5.8097 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9049 mL 14.5243 mL 29.0487 mL 72.6216 mL
5 mM 0.5810 mL 2.9049 mL 5.8097 mL 14.5243 mL
10 mM 0.2905 mL 1.4524 mL 2.9049 mL 7.2622 mL
15 mM 0.1937 mL 0.9683 mL 1.9366 mL 4.8414 mL
20 mM 0.1452 mL 0.7262 mL 1.4524 mL 3.6311 mL
25 mM 0.1162 mL 0.5810 mL 1.1619 mL 2.9049 mL
30 mM 0.0968 mL 0.4841 mL 0.9683 mL 2.4207 mL
40 mM 0.0726 mL 0.3631 mL 0.7262 mL 1.8155 mL
50 mM 0.0581 mL 0.2905 mL 0.5810 mL 1.4524 mL
60 mM 0.0484 mL 0.2421 mL 0.4841 mL 1.2104 mL
80 mM 0.0363 mL 0.1816 mL 0.3631 mL 0.9078 mL
100 mM 0.0290 mL 0.1452 mL 0.2905 mL 0.7262 mL
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Bromopride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromopride4093-35-0Dopamine ReceptorInhibitorinhibitorinhibit

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