2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. MK 287

MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis.

For research use only. We do not sell to patients.

MK 287

MK 287 Chemical Structure

CAS No. : 135947-75-0

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MK 287 Related Antibodies

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Description

MK 287 is a potent, selective and orally active antagonist of platelet-activating factor receptor (PAFR). MK 287 can inhibit [3H]C18-PAF binding to human platelet, polymorphonuclear leukocyte (PMN) and lung membranes with K1 values of 6.1, 3.2, and 5.49 nM, respectively. MK 287 can inhibit PAF-induced aggregation of platelets in plasma or gel-filtered platelets and elastase release from PMNs with ED50 values of 56, 1.5 and 4.4 nM. MK 287 can be used for the research of cardiovascular disease, such as thrombosis[1].

Molecular Weight

510.60

Formula

C25H34O9S
CAS No.
SMILES

CCCOC1=C(C=C([C@H]2O[C@H](C3=CC(OC)=C(C(OC)=C3)OC)CC2)C=C1OC)S(CCO)(=O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MK 287 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK 287135947-75-0MK287MK-287Platelet-activating Factor Receptor (PAFR)platelet-activating factor receptorPAFRpolymorphonuclear leukocyteplatelets aggregationelastasePMNsthrombosisInhibitorinhibitorinhibit

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