2. GPCR/G Protein
  3. Leukotriene Receptor
  4. SC-53228

SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis.

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SC-53228

SC-53228 Chemical Structure

CAS No. : 153633-01-3

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SC-53228 Related Antibodies

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LTB4 LTC4/CysLT2 LTD4/CysLT1 LTE4

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Description

SC-53228 is an orally active human leukotriene B4 receptor (LTB4 receptor) antagonist. SC-53228 exerts its anti-inflammatory effect by specifically blocking the LTB4 receptor and inhibiting neutrophil infiltration. SC-53228 has demonstrated significant efficacy and good safety in various inflammatory models. SC-53228 can be used for a variety of inflammatory diseases, such as psoriasis and ulcerative colitis[1][2].

In Vivo

SC-53228 (20 mg/kg, p.o., twice daily for 56 days) demonstrates significant anti-inflammatory effects and excellent safety in the spontaneous colitis model of cotton-topped marmosets[1].
SC-53228 (100-1000 μg or 1% gel, topical administration; 2.5-10 mg/kg (mice), 40 mg/kg (monkey) p.o., single dose or once daily for 5 days) demonstrates significant anti-inflammatory effects in the psoriasis models of mice, guinea pigs, and rhesus monkeys and both local and oral administration could rapidly inhibit inflammation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneous colitis model established in Cotton-top tamarins, Saguinus Oedipus[1]
Dosage: 20 mg/kg
Administration: Oral administration (p.o.), twice daily for 56 days
Result: Significantly improved colitis, weight gain, and improved stool consistency.
Significantly reduced the inflammatory index, eliminate neutrophils, restore mucus production, and promote mucosal regeneration.
Molecular Weight

539.66

Formula

C31H41NO7
CAS No.
SMILES

CCCC1=C2C(CC[C@H](O2)CCC(O)=O)=CC=C1OCCCOC3=C(C(OC)=C(C=C3)C(NC)=O)CC4CC4
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SC-53228 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SC-53228153633-01-3SC53228SC 53228Leukotriene ReceptorLTB4 receptor antagonismdermal and colonic inflammation modelsmyeloperoxidase activitytopical and oral efficacypsoriasisinflammatory bowel diseaseInhibitorinhibitorinhibit

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