2. Cell Cycle/DNA Damage Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease
  3. PPAR
  4. Leriglitazone hydrochloride

Leriglitazone hydrochloride  (Synonyms: MIN-102 hydrochloride; Hydroxypioglitazone hydrochloride)

Cat. No.: HY-117727A Purity: 99.64%
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Leriglitazone (MIN-102; Hydroxypioglitazone) hydrochloride is an orally active and a BBB-penetrable PPARγ agonist with an EC50 of 9 μM. Leriglitazone hydrochloride, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone hydrochloride can be used in the study of neuroinflammatory and neurodegenerative diseases.

For research use only. We do not sell to patients.

Leriglitazone hydrochloride

Leriglitazone hydrochloride Chemical Structure

CAS No. : 146062-46-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Based on 1 publication(s) in Google Scholar

Other Forms of Leriglitazone hydrochloride:

Leriglitazone hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Leriglitazone (MIN-102; Hydroxypioglitazone) hydrochloride is an orally active and a BBB-penetrable PPARγ agonist with an EC50 of 9 μM. Leriglitazone hydrochloride, as a regulator of mitochondrial function, has neuroprotective, anti-inflammatory and antioxidant effects. Leriglitazone hydrochloride can be used in the study of neuroinflammatory and neurodegenerative diseases[1][2][3][4].

IC50 & Target[4]

PPAR-γ

9 μM (EC50)

In Vitro

Leriglitazone (100 nM; 45 days) hydrochloride increases PKAN astrocyte activity and respiratory activity, and reduces iron accumulation[1].
Leriglitazone (50-500 nM; 5 days) hydrochloride increases Frataxin levels, promots cell survival and improves neuronal degeneration and mitochondrial function in Frataxin-deficient DRG neurons[2].
Leriglitazone (0.5-2 μM; 7 days) hydrochloride prevents lipid droplet accumulation in frataxin-deficient cardiomyocytes[2].
Leriglitazone (100-500 nM; 48 h) hydrochloride regulates the expression of PPARγ signaling pathway related genes, increases mitochondrial function and reduces oxidative damage in Rett fibroblasts[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Leriglitazone hydrochloride Related Antibodies

Western Blot Analysis[2]

Cell Line: Frataxin-deficient DRG neurons
Concentration: 500 nM
Incubation Time: 5 days
Result: Increased the level of frataxin.
In Vivo

Leriglitazone (50 mg/kg; Feed administration; 8 months) hydrochloride improves motor impairment in a Friedreich ataxia mouse model[2].
Leriglitazone (75 mg/kg; Feed administration; 7 months) hydrochloride has an improved effect in Rett mouse model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: YG8sR mice[2]
Dosage: 50 mg/kg
Administration: Feed administration; 8 months
Result: Did not change the weight gain of YG8sR mice.
Improved the performance of the YG8sR mice in the case of the balance beam test.
Animal Model: Rett female mice[3]
Dosage: 75 mg/kg
Administration: Feed administration; 7 months
Result: Corrected the defect of ATP concentration and lipid peroxidation in hippocampus and cerebellum.
Reduce the level of 8-OHdG, ROS, MnSOD and GPX.
Improved overall health and exploratory behavior in mice.
Clinical Trial
Molecular Weight

408.90

Formula

C19H21ClN2O4S
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(N1)SC(CC2=CC=C(OCCC3=NC=C(C(O)C)C=C3)C=C2)C1=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (122.28 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4456 mL 12.2279 mL 24.4559 mL
5 mM 0.4891 mL 2.4456 mL 4.8912 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.64%

SDS (252 KB)

COA (246 KB) HNMR (140 KB) RP-HPLC (169 KB) LCMS (383 KB) Elemental Analysis Report (104 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4456 mL 12.2279 mL 24.4559 mL 61.1396 mL
5 mM 0.4891 mL 2.4456 mL 4.8912 mL 12.2279 mL
10 mM 0.2446 mL 1.2228 mL 2.4456 mL 6.1140 mL
15 mM 0.1630 mL 0.8152 mL 1.6304 mL 4.0760 mL
20 mM 0.1223 mL 0.6114 mL 1.2228 mL 3.0570 mL
25 mM 0.0978 mL 0.4891 mL 0.9782 mL 2.4456 mL
30 mM 0.0815 mL 0.4076 mL 0.8152 mL 2.0380 mL
40 mM 0.0611 mL 0.3057 mL 0.6114 mL 1.5285 mL
50 mM 0.0489 mL 0.2446 mL 0.4891 mL 1.2228 mL
60 mM 0.0408 mL 0.2038 mL 0.4076 mL 1.0190 mL
80 mM 0.0306 mL 0.1528 mL 0.3057 mL 0.7642 mL
100 mM 0.0245 mL 0.1223 mL 0.2446 mL 0.6114 mL
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Leriglitazone hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Leriglitazone146062-46-6MIN-102HydroxypioglitazoneMIN102MIN 102PPARPeroxisome proliferator-activated receptorsMetabolitePPARγ LBDInhibitorinhibitorinhibit

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