2. Others Neuronal Signaling
  3. Cholinesterase (ChE) Isotope-Labeled Compounds
  4. Rivastigmine-d4 tartrate

Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease.

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Rivastigmine-d<sub>4</sub> tartrate Chemical Structure

Rivastigmine-d4 tartrate Chemical Structure

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Rivastigmine-d4 tartrate Related Antibodies

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Description

Rivastigmine-d4 (tartrate) is deuterium labeled Rivastigmine (tartrate). Rivastigmine tartrate (ENA 713; SDZ-ENA 713) is an orally active and potent cholinesterase (ChE) inhibitor and inhibits butyrylcholinesterase (BChE) and acetylcholinesteras (AChE) with IC50s of 0.037 μM, 4.15 μM, respectively. Rivastigmine tartrate can pass the blood brain barrier (BBB). Rivastigmine tartrate is a parasympathomimetic or cholinergic agent used for the research of mild to moderate dementia of the Alzheimer's type and dementia due to Parkinson's disease[1][2][3].

Molecular Weight

404.45

Formula

C18H24D4N2O8
Unlabeled CAS
SMILES

CCN(C(OC1=CC([C@@H](N(C([2H])([H])[2H])C([2H])([H])[2H])C)=CC=C1)=O)C.O[C@H]([C@@H](O)C(O)=O)C(O)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (123.62 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4725 mL 12.3625 mL 24.7249 mL
5 mM 0.4945 mL 2.4725 mL 4.9450 mL
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In Vivo Dissolution Calculator
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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation
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Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 2.4725 mL 12.3625 mL 24.7249 mL 61.8123 mL
5 mM 0.4945 mL 2.4725 mL 4.9450 mL 12.3625 mL
10 mM 0.2472 mL 1.2362 mL 2.4725 mL 6.1812 mL
15 mM 0.1648 mL 0.8242 mL 1.6483 mL 4.1208 mL
20 mM 0.1236 mL 0.6181 mL 1.2362 mL 3.0906 mL
25 mM 0.0989 mL 0.4945 mL 0.9890 mL 2.4725 mL
30 mM 0.0824 mL 0.4121 mL 0.8242 mL 2.0604 mL
40 mM 0.0618 mL 0.3091 mL 0.6181 mL 1.5453 mL
50 mM 0.0494 mL 0.2472 mL 0.4945 mL 1.2362 mL
60 mM 0.0412 mL 0.2060 mL 0.4121 mL 1.0302 mL
80 mM 0.0309 mL 0.1545 mL 0.3091 mL 0.7727 mL
100 mM 0.0247 mL 0.1236 mL 0.2472 mL 0.6181 mL
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Rivastigmine-d4 tartrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rivastigmine-d4Cholinesterase (ChE)Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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