S-Adenosyl-L-methionine iodide (Synonyms: S-Adenosyl methionine iodide; Ademetionine iodide; AdoMet iodide)

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Data Sheet
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COA
Handling Instructions Technical Support

S-Adenosyl-L-methionine (S-Adenosyl methionine) iodide is an orally active methyl group donor. S-Adenosyl-L-methionine iodide is a dietary supplement with potent antidepressant effects. S-Adenosyl-L-methionine iodide also has anti‑proliferative, pro‑apoptotic and anti‑metastatic roles in cancers. S-Adenosyl-L-methionine iodide has the potential for, cancer, liver disease and osteoarthritis research.

For research use only. We do not sell to patients.

S-Adenosyl-L-methionine iodide Chemical Structure

CAS No. : 3493-13-8

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Other In-stock Forms of S-Adenosyl-L-methionine iodide:

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Other Forms of S-Adenosyl-L-methionine iodide:

S-Adenosyl-L-methionine In-stock
S-Adenosyl-L-methionine disulfate tosylate In-stock
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13 Publications Citing Use of MCE S-Adenosyl-L-methionine iodide

: S-Adenosyl-L-methionine iodide purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2021 Mar 22;95:107545. [Abstract]; S-adenosylmethionine (SAMe) application at 30 min prior to high glucose treatment significantly increased H2S levels compared with the HG group. The cystathionine-β-synthase (CBS) level is obviously elevated in HG + SAMe group compared with the HG group.

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Description

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

S-Adenosyl-L-methionine (300 µM, 24 or 48 h) iodide induces cell apoptosis, and promotes the cell cycle arrest in Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (300 µM, 24 h) iodide decreases the migration of the Cal-33 and JHU-SCC-011 cells^[4].
S-Adenosyl-L-methionine (5-40 μg/mL, 48 h) iodide protects the anticancer effect of 5‑FU by regulating the expression of DNMTs^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[4]

Cell Line:	Cal-33 and JHU-SCC-011 cells
Concentration:	300 µM
Incubation Time:	24 h (Cal-33) or 48 h (HU-SCC-011)
Result:	Showed an approximately 10% and 3%of apoptotic cells respectively.

Western Blot Analysis^[4]

Cell Line:	Cal-33 and JHU-SCC-011 cells
Concentration:	300 µM
Incubation Time:	24 h (Cal-33) or 48 h (HU-SCC-011)
Result:	Decreased the expression of cyclin B1, E1 and D1 in the Cal-33 and JHU-SCC-011 cells.

In Vivo

S-Adenosyl-L-methionine (30 mg/kg, p.o., for 3 days) iodide prevents ASD like behaviors induced by early postnatal Valproic acid (HY-10585) exposure in young mice^[6].
S-Adenosyl-L-methionine (50 and 100 mg/kg, p.o.) iodide shows antiepileptic, memory-enhancing, and antioxidant properties in a Pentylenetetrazole-induced rat epilepsy model^[7].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Valproic acid treated young mice^[6]
Dosage:	30 mg/kg
Administration:	p.o., for 3 days
Result:	Alleviated most ASD like neurobehavioral symptoms. Normalized the redox potential in the prefrontal cortex.

Clinical Trial

Molecular Weight

526.35

Formula

C₁₅H₂₃IN₆O₅S

CAS No.

3493-13-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1C[S+](CC[C@H](N)C(O)=O)C.[I-]

Structure Classification

Others

Initial Source

Endogenous metabolite

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Purity & Documentation

Purity: 84%

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Data Sheet (279 KB) SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. W Wang, et al. Reversed-phase high-performance liquid chromatography procedure for the simultaneous determination of S-adenosyl-L-methionine and S-adenosyl-L-homocysteine in mouse liver and the effect of methionine on their concentrations. J Chromatogr B Biomed Sci Appl. 2001 Oct 5;762(1):59-65. [Content Brief]

[2]. Wadie I Najm, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. [Content Brief]

[3]. Shelly C Lu, et al. S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev. 2012 Oct;92(4):1515-42. [Content Brief]

[4]. Mosca L, et al. Effects of S‑adenosyl‑L‑methionine on the invasion and migration of head and neck squamous cancer cells and analysis of the underlying mechanisms. Int J Oncol. 2020 May;56(5):1212-1224. [Content Brief]

[5]. Ham MS, et al. S-adenosyl methionine specifically protects the anticancer effect of 5-FU via DNMTs expression in human A549 lung cancer cells. Mol Clin Oncol. 2013 Mar;1(2):373-378. [Content Brief]

[6]. Ornoy A, et al. S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice. Neurotoxicol Teratol. 2019 Jan-Feb;71:64-74. [Content Brief]

[7]. Dhediya RM, et al. Evaluation of antiepileptic effect of S-adenosyl methionine and its role in memory impairment in pentylenetetrazole-induced kindling model in rats. Epilepsy Behav. 2016 Aug;61:153-157. [Content Brief]

S-Adenosyl-L-methionine iodide Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

S-Adenosyl-L-methionine3493-13-8S-Adenosyl methionineAdemetionineAdoMetEndogenous MetaboliteApoptosisInhibitorinhibitorinhibit

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