2. Membrane Transporter/Ion Channel Neuronal Signaling Apoptosis Immunology/Inflammation MAPK/ERK Pathway
  3. iGluR Apoptosis COX p38 MAPK
  4. Crocetin

Crocetin  (Synonyms: Transcrocetin; trans-Crocetin)

Cat. No.: HY-N2072 Purity: 98.07%
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Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia.

For research use only. We do not sell to patients.

Crocetin

Crocetin Chemical Structure

CAS No. : 27876-94-4

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Crocetin:

Crocetin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Crocetin

View All iGluR Isoform Specific Products:

View All Isoforms
AMPA Receptor NMDA Receptor Kainate Receptor

View All COX Isoform Specific Products:

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COX COX-1 COX-2 COX-3

View All p38 MAPK Isoform Specific Products:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia[1][2][3][4].

IC50 & Target[1]

NMDA Receptor

 

COX-2

 

Cellular Effect
Cell Line Type Value Description References
RAW264.7 IC50
5.99 μM
Compound: 18
Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
Inhibition of nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 cells by Griess reaction based method
[PMID: 23305920]
In Vitro

Crocetin (1-100 μM, 24 h) inhibits COX-2 expression in HeLa cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Crocetin Related Antibodies

RT-PCR[1]

Cell Line: HeLa cells
Concentration: 1, 10, 50 and 100 μM
Incubation Time: 24 h
Result: Reduced COX-2 mRNA levels.
In Vivo

Crocetin (10-40 mg/kg, p.o., twice a day for 35 days) shows preventive and an anti-inflammation effect in methylcholanthrene (MCA)-induced uterine cervix tumor mice models[1].
Crocetin (20 mg/kg, p.o., 1 h before ischemia) inhibits retinal ischemic damage in ischemia/reperfusion-induced mice models[2].
Crocetin (25 mg/mL, p.o., daily) delays brain and body aging in aged C57BL/6J mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Methylcholanthrene- (MCA)-induced uterine cervix tumor mice models[1]
Dosage: 10, 20 and 40 mg/kg
Administration: Orally administration, twice a day for 35 days
Result: Decreased MDA levels.
Decreased PMNs activity.
Reduced IL-1β, TNF-α and iNOS levels.
Animal Model: Ischemia/reperfusion-induced mice models[2]
Dosage: 20 mg/kg
Administration: Orally administration, 1 h before ischemia
Result: Prevented the reduction in IPL thickness.
Prevented the induction of cell apoptosis.
Inhibited functional damage and DNA oxidation in the retina.
Prevented the activation of MAPK and redox-sensitive transcription factors in the retina.
Animal Model: Aged C57BL/6J mice[3]
Dosage: 25 mg/mL
Administration: Orally administration, daily
Result: Increased ATP and NAD+ levels.
Upregulated the electron transport chain to yield more energy.
Restored the ETC function of mitochondria.
Attenuated the basal level of oxidative stress.
Molecular Weight

328.40

Formula

C20H24O4
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(O)/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (60.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0451 mL 15.2253 mL 30.4507 mL
5 mM 0.6090 mL 3.0451 mL 6.0901 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC/saline water

    Solubility: 10 mg/mL (30.45 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0451 mL 15.2253 mL 30.4507 mL 76.1267 mL
5 mM 0.6090 mL 3.0451 mL 6.0901 mL 15.2253 mL
10 mM 0.3045 mL 1.5225 mL 3.0451 mL 7.6127 mL
15 mM 0.2030 mL 1.0150 mL 2.0300 mL 5.0751 mL
20 mM 0.1523 mL 0.7613 mL 1.5225 mL 3.8063 mL
25 mM 0.1218 mL 0.6090 mL 1.2180 mL 3.0451 mL
30 mM 0.1015 mL 0.5075 mL 1.0150 mL 2.5376 mL
40 mM 0.0761 mL 0.3806 mL 0.7613 mL 1.9032 mL
50 mM 0.0609 mL 0.3045 mL 0.6090 mL 1.5225 mL
60 mM 0.0508 mL 0.2538 mL 0.5075 mL 1.2688 mL
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Crocetin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Crocetin27876-94-4Transcrocetin trans-CrocetiniGluRApoptosisCOXp38 MAPKIonotropic glutamate receptorsCyclooxygenaseCrocus sativus LNMDACOX-2MAPKCervical cancerIschemiaInhibitorinhibitorinhibit

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