2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel iGluR
  4. FP802 hydrochloride

FP802 hydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 hydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology. FP802 hydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS). FP802 hydrochloride can be used for AD and ALS research[1][2].

For research use only. We do not sell to patients.

FP802 hydrochloride

FP802 hydrochloride Chemical Structure

CAS No. : 2490401-57-3

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of FP802 hydrochloride:

FP802 hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPC TRPM TRPV TRPA TRPML

View All iGluR Isoform Specific Products:

View All Isoforms
AMPA Receptor NMDA Receptor Kainate Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

FP802 hydrochloride is an orally active potent TwinF interface inhibitor that disrupts and detoxifies the NMDAR/TRPM4 death complex. FP802 hydrochloride exerts powerful neuroprotective effects in the 5xFAD mouse model of Alzheimer’s disease (AD) by preventing cognitive decline, preserving neuronal structural integrity, reducing amyloid-β plaque formation, and mitigating mitochondrial pathology[1]. FP802 hydrochloride stops loss of motor neurons, reduces serum neurofilament light chain (NfL) levels, improves motor performance, and extends life in a mouse model of amyotrophic lateral sclerosis (ALS)[2]. FP802 hydrochloride can be used for AD and ALS research[1][2].

In Vitro

FP802 (8 μM, 24-72 h) hydrochloride disrupts the NMDAR/TRPM4 complex and provides neuroprotection in cellular models, without directly affecting neurite outgrowth[1].
FP802 (10 μM, 30 min) hydrochloride exhibits potent neuroprotection against glutamate (20 μM)-mediated toxicity (IC50 = 8.7 µM) and restores NMDA-suppressed immediate-early gene expression to physiological levels[2].
FP802 hydrochloride shows no antagonistic activity against NMDARs in HEK293 cells (IC50 > 250 μM for both, GluN1/GluN2A and GluN1/GluN2B)[2].
FP802 (30 min) hydrochloride dose-dependently blocks NMDA-induced death of post-mitotic neurons in forebrain organoids derived from sporadic ALS patient Induced Pluripotent Stem Cells (iPSCs)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FP802 hydrochloride Related Antibodies

Real Time qPCR[1]

Cell Line: mouse cortical neurons
Concentration: 10 μM
Incubation Time: 30 min
Result: Eliminated the transcriptional shut-off induced by eNMDARs and boosted the NMDA bath application-induced expression of the immediate-early genes (IEGs) Atf3, Arc, Bdnf, cFos, Inhibin beta A, and Npas4 to reach levels that were comparable to those achieved by Bicuculline (HY-N0219)-induced action potential bursting.
In Vivo

FP802 (10 and 40 mg/kg, p.o., daily for 4 months) hydrochloride rescues cognitive function, prevents neuronal structure degeneration, and reduces amyloid pathology in 5xFAD mice[1].
FP802 (40 mg/kg, s.c., daily from ~week 15 for 4 weeks) hydrochloride safely halts motor neuron degeneration and extends survival in ALS mice by targeting the NMDAR/TRPM4 complex[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5xFAD transgenic mice and wild-type littermates[1]
Dosage: 10 and 40 mg/kg
Administration: p.o., daily for 4 months
Result: Showed no apparent adverse effects on the liver, kidney, or heart.
Reduced the complex formation of GluN2B with TRPM4 in the 5xFAD mice at both 10 and 40 mg/kg.
Reduced complex formation of GluN2A with TRPM4 at 40 mg/kg.
Significantly decreased the interaction between NMDAR and TRPM4 without affecting the total protein levels of GluN2A, GluN2B, or TRPM4.
Led to a significant increase in the time 5xFAD mice spent in the target quadrant and the frequency with which they crossed the platform's prior location at the dose of 40 mg/kg, compared to vehicle.
Increased the time 5xFAD mice spent exploring the novel object in the Novel Object Recognition (NOR) test and the displaced object in the Novel Location Recognition (NLR) test relative to vehicle treatment.
Prevented the shift of mitochondrial morphologies from normal to pathological phenotypes in both CA1 and CA3.
Effectively preserved dendritic trees in 5xFAD mice as compared to controls, as demonstrated by increased total dendritic length and numbers of crossings in the Sholl analysis.
Prevented the increase in the density of 'apparent orphaned synapses' in both stratum oriens (CA1 basal dendrites) and stratum radiatum (CA1 apical dendrites) of 5xFAD mice.
Prevented the loss of excitatory and inhibitory synapses and the associated structural deterioration of postsynaptic densities (PSD) in the basal and apical dendrites of CA1 neurons, thereby preserving synaptic integrity in 5xFAD mice.
Led to a 25-40 % reduction in Aβ plaque load, significantly limiting plaque development without completely preventing its formation.
Animal Model: Male SOD1G93A transgenic mice and wild-type littermates[2]
Dosage: 40 mg/kg
Administration: s.c., daily from ~week 15 for 4 weeks
Result: Disrupted he interaction of TRPM4 with the NMDAR subunit GluN2B in mice spinal cord.
Significantly better neurological scores and less body weight loss than vehicle-treated controls.
Significantly improved motor performance (increased total distance traveled and rearing frequency in the open field).
Significantly extended the lifespan of SOD1G93A mice (survival median increased from 151 to 164 days).
Preserved larger soma sizes of lumbar spinal motor neurons compared to the control group at week 19.
Significantly reduced serum NfL levels while showing no effect on spinal microglial response or EAAT2 expression.
Showed no adverse effects on liver, kidney, heart, or blood counts.
Molecular Weight

285.64

Formula

C11H19Cl3N2
CAS No.
SMILES

CCN(CC1=CC(Cl)=CC=C1)CCN.Cl.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 116.67 mg/mL (408.45 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5009 mL 17.5046 mL 35.0091 mL
5 mM 0.7002 mL 3.5009 mL 7.0018 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5009 mL 17.5046 mL 35.0091 mL 87.5228 mL
5 mM 0.7002 mL 3.5009 mL 7.0018 mL 17.5046 mL
10 mM 0.3501 mL 1.7505 mL 3.5009 mL 8.7523 mL
15 mM 0.2334 mL 1.1670 mL 2.3339 mL 5.8349 mL
20 mM 0.1750 mL 0.8752 mL 1.7505 mL 4.3761 mL
25 mM 0.1400 mL 0.7002 mL 1.4004 mL 3.5009 mL
30 mM 0.1167 mL 0.5835 mL 1.1670 mL 2.9174 mL
40 mM 0.0875 mL 0.4376 mL 0.8752 mL 2.1881 mL
50 mM 0.0700 mL 0.3501 mL 0.7002 mL 1.7505 mL
60 mM 0.0583 mL 0.2917 mL 0.5835 mL 1.4587 mL
80 mM 0.0438 mL 0.2188 mL 0.4376 mL 1.0940 mL
100 mM 0.0350 mL 0.1750 mL 0.3501 mL 0.8752 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

FP802 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FP8022490401-57-3FP 802FP-802TRP ChanneliGluRTransient receptor potential channelsIonotropic glutamate receptorsTwinF interface inhibitorNMDAR/TRPM4neuroprotective5xFADADamyloid-β plaquemitochondrialNfLALSiPSCsorganoidsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
FP802 hydrochloride
Cat. No.:
HY-W611371A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.