2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. Tilivapram

Tilivapram (AVE8112) is an orally active PDE4 inhibitor. Tilivapram can regulate neurophysiological activities and improve cognitive and memory impairments. Tilivapram can be used in the research of various neuropsychiatric disorders such as schizophrenia and Parkinson's disease.

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Tilivapram

Tilivapram Chemical Structure

CAS No. : 166741-91-9

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Based on 1 publication(s) in Google Scholar

Tilivapram Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

View All Isoforms
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

Tilivapram (AVE8112) is an orally active PDE4 inhibitor. Tilivapram can regulate neurophysiological activities and improve cognitive and memory impairments. Tilivapram can be used in the research of various neuropsychiatric disorders such as schizophrenia and Parkinson's disease[1].

IC50 & Target[1]

PDE4

 

Molecular Weight

384.21

Formula

C16H15Cl2N3O4
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

ClC1=C(NC(C2=NC=C(OC)C(OCC3CC3)=C2)=O)C(Cl)=C[N+]([O-])=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (130.14 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6027 mL 13.0137 mL 26.0274 mL
5 mM 0.5205 mL 2.6027 mL 5.2055 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6027 mL 13.0137 mL 26.0274 mL 65.0686 mL
5 mM 0.5205 mL 2.6027 mL 5.2055 mL 13.0137 mL
10 mM 0.2603 mL 1.3014 mL 2.6027 mL 6.5069 mL
15 mM 0.1735 mL 0.8676 mL 1.7352 mL 4.3379 mL
20 mM 0.1301 mL 0.6507 mL 1.3014 mL 3.2534 mL
25 mM 0.1041 mL 0.5205 mL 1.0411 mL 2.6027 mL
30 mM 0.0868 mL 0.4338 mL 0.8676 mL 2.1690 mL
40 mM 0.0651 mL 0.3253 mL 0.6507 mL 1.6267 mL
50 mM 0.0521 mL 0.2603 mL 0.5205 mL 1.3014 mL
60 mM 0.0434 mL 0.2169 mL 0.4338 mL 1.0845 mL
80 mM 0.0325 mL 0.1627 mL 0.3253 mL 0.8134 mL
100 mM 0.0260 mL 0.1301 mL 0.2603 mL 0.6507 mL
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Tilivapram Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tilivapram166741-91-9AVE8112AVE 8112AVE-8112Phosphodiesterase (PDE)PDE4schizophreniaParkinson's diseaseInhibitorinhibitorinhibit

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