Arimoclomol citrate (Synonyms: BRX-220 citrate)

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Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.

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Arimoclomol citrate Chemical Structure

CAS No. : 368860-21-3

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Other Forms of Arimoclomol citrate:

Arimoclomol Get quote
Arimoclomol maleate Get quote

3 Publications Citing Use of MCE Arimoclomol citrate

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Description

Arimoclomol citrate (BRX-220 citrate) is an orally active co-inducer of heat shock proteins (HSP)^[1]. Arimoclomol citrate protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system^[2]. Arimoclomol citrate can be used for the study of Niemann–Pick disease type C.

IC₅₀ & Target^[1]

HSP

In Vivo

Arimoclomol (BRX-220; 20 mg/kg; orally administered for 5 d) has a protective effect against cholecystokinin-octapeptide (CCK)-induced acute pancreatitis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 240 to 270 g^[1]
Dosage:	20 mg/kg
Administration:	Administered intragastrically, for 5 days
Result:	Had a protective effect against CCK-induced acute pancreatitis.

Clinical Trial

Molecular Weight

505.90

Formula

C₂₀H₂₈ClN₃O₁₀

CAS No.

368860-21-3

SMILES

Cl/C(C1=C[N+]([O-])=CC=C1)=N\OC[C@H](O)CN2CCCCC2.O=C(CC(C(O)=O)(O)CC(O)=O)O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rakonczay Z Jr, et al. Nontoxic heat shock protein coinducer BRX-220 protects against acute pancreatitis in rats. Free Radic Biol Med. 2002 Jun 15;32(12):1283-92. [Content Brief]

[2]. Phukan J. Arimoclomol, a coinducer of heat shock proteins for the potential treatment of amyotrophic lateral sclerosis. IDrugs. 2010 Jul;13(7):482-96. [Content Brief]

Arimoclomol citrate Related Classifications

Neurological Disease Metabolic Disease Inflammation/Immunology

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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