PBT434 free base (Synonyms: ATH434 free base)

Cat. No.: HY-120475B: Data Sheet Handling Instructions
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PBT434 (ATH434) (free base) is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 (free base) can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 (free base) inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 (free base) prevents the loss of substantia nigra pars compacta neurons (SNpc). PBT434 (free base) has the potential for the research of Parkinson’s disease (PD).

For research use only. We do not sell to patients.

PBT434 free base Chemical Structure

CAS No. : 1232840-87-7

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Other In-stock Forms of PBT434 free base:

PBT434 PBT434 mesylate

Other Forms of PBT434 free base:

PBT434 In-stock
PBT434 mesylate In-stock

2 Publications Citing Use of MCE PBT434 free base

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•Related Small Molecules:

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α-synuclein α-synuclein Aggregation α-synuclein/CHMP2B

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Description

IC₅₀ & Target

α-synuclein Aggregation

Molecular Weight

302.16

Formula

C₁₂H₁₃Cl₂N₃O₂

CAS No.

1232840-87-7

SMILES

O=C1N(C)C(CNCC)=NC2=C1C(Cl)=CC(Cl)=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Finkelstein DI, et al. The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. Acta Neuropathol Commun. 2017 Jun 28;5(1):53. [Content Brief]

[2]. Bailey DK, et al. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS One. 2021 Jul 26;16(7):e0254794. [Content Brief]

PBT434 free base Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PBT4341232840-87-7ATH434PBT 434PBT-434ATH 434ATH-434α-synucleinα-Synorally activecross the blood-brain barrierSNpcironParkinson’s diseaseInhibitorinhibitorinhibit

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