Sodium oxalate,ACS,99.5%  (Synonyms: Ethanedioic acid sodium,ACS, 99.5%)

Sodium oxalate is an orally active dispersant and coordination agent. Sodium oxalate causes mitochondrial dysfunction. Sodium oxalate has catalytic enhancing activity. Sodium oxalate induces stable chronic kidney disease. Sodium oxalate induces highly malignant and undifferentiated breast tumors^{[1][2][3][4][5][6][7][8]}.

Sodium oxalate (1-4 mM; 1-24 h) leads to time- and concentration-dependent decrease in cell survival, inhibits proliferation in LLCPK1, MDCK, renal fibroblast and endothelial cells^[2].
Sodium oxalate (0.1-2 mM; 24 h) causes mitochondrial dysfunction, reduces basal OCR and ATP-linked OCR in THP-1 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium oxalate (Oxalic acid form; 810 μM; injected into mammary fatpad; every 3-4 days; 9 times, 29 days) induces highly malignant and undifferentiated breast tumors in female BALB/c or BALB/c nude mice^[4].
Sodium oxalate (Oxalic acid form; 0.5 mmol/kg; i.p.; once daily for 5 consecutive days) combined with DMSA reverses GaAs-induced oxidative stress, reducing arsenic and gallium levels in tissues of male Wistar albino rats^[6].
Sodium oxalate (50 μmol/g in calcium-free diet; p.o.) induces stable chronic kidney disease in C57BL/6 mice^[7].
Sodium oxalate (70 mg/kg body weight; p.o. in drinking water; 30 days) induces urolithiasis in male mice, increasing serum uric acid, creatinine, sodium, phosphate, oxalate levels and renal sodium, phosphate, oxalate deposition ^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

134.00

C₂Na₂O₄

62-76-0

Solid

White to off-white

O=C(O[Na])C(O[Na])=O

Room temperature in continental US; may vary elsewhere.

Store at room temperature, keep dry and cool

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

• [1]. Bai Z, et al. Electrooxidation of formic acid catalyzed by Pd Nanoparticles supported on multi-walled carbon nanotubes with sodium oxalate. Ionics, 2013, 19(3): 543-548.

  [2]. Knoll T, et al. The influence of oxalate on renal epithelial and interstitial cells. Urol Res. 2004 Aug;32(4):304-9.  [Content Brief]

  [3]. Patel M, et al. Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line. Redox Biol. 2018 May;15:207-215.  [Content Brief]

  [4]. Castellaro AM, et al. Oxalate induces breast cancer. BMC Cancer. 2015 Oct 22;15:761.  [Content Brief]

  [5]. Heller A, et al. Oxalic acid has an additional, detoxifying function in Sclerotinia sclerotiorum pathogenesis. PLoS One. 2013 Aug 12;8(8):e72292.  [Content Brief]

  [6]. Flora SJ, et al. Combined administration of oxalic acid, succimer and its analogue for the reversal of gallium arsenide-induced oxidative stress in rats. Arch Toxicol. 2002 Jun;76(5-6):269-76.  [Content Brief]

  [7]. Mulay SR, et al. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F785-F795.  [Content Brief]

  [8]. Kamil M A, et al. Pharmacological evaluation of aqueous extract of plant formulation against sodium oxalate induced urolithiasis in mice[J]. Int J Original Res, 2016, 2(2): 32-39.