2. Metabolic Enzyme/Protease
  3. Angiotensin-converting Enzyme (ACE) Acetyl-CoA Carboxylase Mitochondrial Metabolism
  4. IRW

IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation.

For research use only. We do not sell to patients.

IRW

IRW Chemical Structure

CAS No. : 159718-10-2

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Description

IRW is an orally active tripeptide produced from egg white with angiotensin converting enzyme (ACE) inhibitory properties. IRW can prevent high-fat diet (HFD)-induced Non-alcoholic fatty liver disease (NAFLD) by modulating hepatic lipid metabolism and increasing mitochondrial content. IRW decreases hepatic triglyceride content and lipid droplet size. IRW increases the hepatic mitochondrial complexes and citrate synthase activity, phosphorylation of 5’-AMP-activated protein kinase and microsomal triglyceride transfer protein abundance. IRW increases phosphorylated acetyl CoA carboxylase and mitochondrial complexes, IRW can be used for the research of inflammation[1].

In Vivo

IRW (45 mg/kg, p.o., daily for 8 weeks) prevents HFD-induced non-alcoholic fatty liver disease (NAFLD) in e C57BL/6 mice with high-fat diet (HFD)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice with high-fat diet (HFD)[1]
Dosage: 45 mg/kg, diet
Administration: Orally administration, daily for 8 weeks
Result: Decreased hepatic triglyceride content and lipid droplet size.
Increased the abundance of hepatic mitochondrial complexes (Ⅰ-Ⅴ) and citrate synthase activity.
Improved glucose tolerance and reduced fasting blood glucose.
Decreased body weight gain and enhanced hepatic phosphorylated acetyl-CoA carboxylase (p-ACC) levels.
Increased adiponectin content in retroperitoneal white adipose tissue (rWAT).
Molecular Weight

473.57

Formula

C23H35N7O4
CAS No.
Sequence

Ile-Arg-Trp
Sequence Shortening

IRW
SMILES

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(O)=O)=O)[C@H]([C@@H](C)CC)N
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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IRW Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRW159718-10-2Angiotensin-converting Enzyme (ACE)Acetyl-CoA CarboxylaseMitochondrial MetabolismACC, Acetyl Coenzyme A Carboxylaseangiotensin converting enzymeACEHFDNAFLDmitochondrial complexestriglyceridecitrate synthase5’-AMP-activated protein kinaseacetyl CoA carboxylaseinflammationInhibitorinhibitorinhibit

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