2. Anti-infection Neuronal Signaling Immunology/Inflammation GPCR/G Protein
  3. Dengue Virus Flavivirus Fungal Bacterial Histamine Receptor
  4. Nimbin

Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections.

For research use only. We do not sell to patients.

Nimbin Chemical Structure

Nimbin Chemical Structure

CAS No. : 5945-86-8

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Nimbin Related Antibodies

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Description

Nimbin is an orally active intermediate limonoid found in Azadirachta. Nimbin prevents tau aggregation and increases cell viability. Nimbin is effective inhibits the envelope protein of dengue virus. Nimbin has anti-inflammatory, antipyretic, antifungal, antihistamine, antiseptic, antioxidant, anti-cancer and anti-viral properties. Nimbin can across blood-brain barrier. Nimbin is promising for research of neurodegenerative diseases and viral infections[1][2][3][4].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 20 μM
Compound: 25
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
AZ-521 cell line IC50
> 20 μM
Compound: 25
Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
SK-BR-3 IC50
> 20 μM
Compound: 25
Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay
[PMID: 21381696]
In Vitro

Nimbin (400 μM; 0-120 h) inhibits β-sheet formation and reduces hydrophobicity in hTau40wt protein in heparin-induced tau aggregation assay[1].
Nimbin (50 nM-50 μM; 24 h) shows no cytotoxicity and rescues tau aggregate-induced cell death in HEK293T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nimbin Related Antibodies

Cell Viability Assay[1]

Cell Line: HEK293T cells
Concentration: 1 μM, 2 μM, 5 μM
Incubation Time: 24 h
Result: Significantly reversed tau aggregate-induced cytotoxicity at 2 μM and 5 μM, restoring cell viability to 100% and 95%, respectively, compared to 32% viability in control groups.
In Vivo

Nimbin reduces brain tau aggregation and improves cognitive behavior in transgenic tauopathy mouse models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

540.60

Formula

C30H36O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]([C@@H]([C@]1(C(C=C2)=O)C)CC(OC)=O)(C3=C4C)[C@@](O[C@]3([H])C[C@@]4([H])C5=COC=C5)([H])[C@@H]([C@@]1([H])[C@]2(C)C(OC)=O)OC(C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

SDS (251 KB)

COA (263 KB)

Handling Instructions (2659 KB)
References
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Nimbin Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nimbin5945-86-8Dengue VirusFlavivirusFungalBacterialHistamine ReceptorDENVTauaggregationintermediatelimonoidAlzheimer'sdiseaseanti-canceranti-viralBBBInhibitorinhibitorinhibit

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