Pterosin A  (Synonyms: (2S)-Pterosin A)

Pterosin A ((2S)-Pterosin A) is a sesquiterpene compound. Pterosin A is an orally active AMPK activator with anti-diabetic effect. Pterosin A can promote glucose uptake, increase serum insulin, and improve hyperglycemia and glucose intolerance. Pterosin A can prevent insulin-secreting cells death and reduce ROS production. Pterosin A can be used for the research of metabolic disease, such as diabetes^[1][2].

Pterosin A (50 μg/mL, 0.5-4 h) enhances glucose uptake and AMPK phosphorylation in muscle cells^[1].
Pterosin A (50-150 μg/mL, 0.5-4 h) inhibits PEPCK expression, triggers the phosphorylations of AMPK, ACC, and GSK-3, decreases glycogen synthase phosphorylation, and increases the intracellular glycogen level in liver cells^[1].
Pterosin A (10-100 μM, 18 h) inhibits H₂O₂-induced ROS production in RINm5f β-cells^[2].
Pterosin A (10-100 μM, 24 h) reduces lipotoxicity-induced cell death in RINm5f β-cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pterosin A (10-100 mg/kg, p.o., daily for 4 weeks) improves hyperglycemia and glucose intolerance in diabetic mica^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

248.32

C₁₅H₂₀O₃

35910-16-8

Solid

White to off-white

O=C1C(C(C[C@](C)1CO)=CC(C)=C2CCO)=C2C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Hsu FL, et al. Antidiabetic effects of pterosin A, a small-molecular-weight natural product, on diabetic mouse models. Diabetes. 2013 Feb;62(2):628-38.  [Content Brief]

  [2]. Chen CY, et al. Chemical constituents analysis and antidiabetic activity validation of four fern species from Taiwan. Int J Mol Sci. 2015 Jan 22;16(2):2497-516.  [Content Brief]