2. MAPK/ERK Pathway NF-κB Metabolic Enzyme/Protease Immunology/Inflammation
  3. MAP3K p38 MAPK NF-κB Reactive Oxygen Species NO Synthase Interleukin Related
  4. Anti-inflammatory agent 102

Anti-inflammatory agent 102 (Compound 11a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 102 exerts its anti-inflammatory effect by blocking the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. Anti-inflammatory agent 102 has significant anti-inflammatory activity and can inhibit the release of NO, ROS, and inflammatory factors (such as IL-6, TNF-α, IL-1β). Anti-inflammatory agent 102 can be used in the study of inflammatory diseases such as ulcerative colitis (UC).

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Anti-inflammatory agent 102 Chemical Structure

Anti-inflammatory agent 102 Chemical Structure

CAS No. : 3053104-47-2

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Anti-inflammatory agent 102 Related Antibodies

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Description

Anti-inflammatory agent 102 (Compound 11a) is an orally active anti-inflammatory agent. Anti-inflammatory agent 102 exerts its anti-inflammatory effect by blocking the activation of the ASK1/p38 MAPKs/NF-κB signaling pathway. Anti-inflammatory agent 102 has significant anti-inflammatory activity and can inhibit the release of NO, ROS, and inflammatory factors (such as IL-6, TNF-α, IL-1β). Anti-inflammatory agent 102 can be used in the study of inflammatory diseases such as ulcerative colitis (UC)[1].

Molecular Weight

333.77

Formula

C16H16ClN3O3
CAS No.
SMILES

COC1=C(N2CCN(C3=CC=CC=N3)C2=O)C=C(Cl)C(OC)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Anti-inflammatory agent 102 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-inflammatory agent 1023053104-47-2MAP3Kp38 MAPKNF-κBReactive Oxygen SpeciesNO SynthaseInterleukin RelatedMAP kinase kinase kinase, MEKK, MAPKKKNuclear factor-κBNuclear factor-kappaBNitric oxide synthasesNOSILASK1InflammationLPSRAW264.7 cellsIBDC57BL/6 miceInhibitorinhibitorinhibit

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