2. Others GPCR/G Protein Neuronal Signaling
  3. Isotope-Labeled Compounds Adrenergic Receptor
  4. Midodrine-d6 hydrochloride

Midodrine-d6 (hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine-d6 (hydrochloride) can strengthen vascular contraction. Midodrine-d6 (hydrochloride) can be used for the researches of cardiovascular disease, such as orthostatic hypotension.

For research use only. We do not sell to patients.

Midodrine-d<sub>6</sub> hydrochloride

Midodrine-d6 hydrochloride Chemical Structure

CAS No. : 1188265-43-1

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Based on 1 publication(s) in Google Scholar

Other Forms of Midodrine-d6 hydrochloride:

Midodrine-d6 hydrochloride Related Antibodies

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Description

Midodrine-d6 (hydrochloride) is a selective and orally active adrenergic α1-receptor agonist. Midodrine-d6 (hydrochloride) can strengthen vascular contraction. Midodrine-d6 (hydrochloride) can be used for the researches of cardiovascular disease, such as orthostatic hypotension[1][2][3].

In Vitro

Midodrine-d6 (hydrochloride) (30 μM, 0-24 h) increases p-AMPK and PPARδ expression in C2C12, HL1 and HepG2 cells[3].
Midodrine-d6 (hydrochloride) (30 μM, 0-1 min) increases Ca2+ in C2C12, HL1 and HepG2 cells[3].
Midodrine-d6 (hydrochloride) (30 μM) increases maximal mitochondrial oxidative phosphorylation and ATP content in C2C12 cells[3].
Midodrine-d6 (hydrochloride) (30-100 μM) reduces cellular lipid content in 3T3-L1 cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Midodrine-d6 hydrochloride Related Antibodies

Western Blot Analysis[1]

Cell Line: C2C12, HL1 and HepG2 cells
Concentration: 30 μM
Incubation Time: 0, 0.5, 1, 3, 6, and 24 h
Result: Increased p-AMPK and PPARδ expression.
In Vivo

Midodrine-d6 (hydrochloride) (20 mg/kg, i.p., 30 mins before Paf) reduces platelet-activating factor (Paf)-induced death in mice[1].
Midodrine-d6 (hydrochloride) (5 mg/kg, i.g.) shows anti-hypotensive effects in orthostatic hypotension rats models[2].
Midodrine-d6 (hydrochloride) (0.3 mg/kg, p.o., 4 weeks.) relieves hypertension in spontaneously hypertensive rats models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Orthostatic hypotension rats models[2]
Dosage: 5 mg/kg
Administration: Orally gavage
Result: Remarkably increased the baselines of SBP, DBP and MAP, but decreased HR.
Animal Model: Spontaneously hypertensive rats models[3]
Dosage: 0.3 mg/kg
Administration: Orally administration, 4 weeks
Result: Increased p-AMPK, PPARδ and PGC-1α expression.
Increased SDH activity and ATP levels.
Increased expression of uncoupling protein 3 (UCP3).
Decreased left ventricular mass and the harvested cardiac weight.
Reduced both systolic and diastolic BP after 1 week.
Reduced serum total cholesterol, LDL cholesterol, and HDL cholesterol.
Molecular Weight

296.78

Formula

C12H13D6ClN2O4
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(CN)=O)C1=CC(OC([2H])([2H])[2H])=CC=C1OC([2H])([2H])[2H].[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (336.95 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3695 mL 16.8475 mL 33.6950 mL
5 mM 0.6739 mL 3.3695 mL 6.7390 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.3695 mL 16.8475 mL 33.6950 mL 84.2375 mL
5 mM 0.6739 mL 3.3695 mL 6.7390 mL 16.8475 mL
10 mM 0.3369 mL 1.6847 mL 3.3695 mL 8.4237 mL
15 mM 0.2246 mL 1.1232 mL 2.2463 mL 5.6158 mL
20 mM 0.1685 mL 0.8424 mL 1.6847 mL 4.2119 mL
25 mM 0.1348 mL 0.6739 mL 1.3478 mL 3.3695 mL
30 mM 0.1123 mL 0.5616 mL 1.1232 mL 2.8079 mL
40 mM 0.0842 mL 0.4212 mL 0.8424 mL 2.1059 mL
50 mM 0.0674 mL 0.3369 mL 0.6739 mL 1.6847 mL
60 mM 0.0562 mL 0.2808 mL 0.5616 mL 1.4040 mL
80 mM 0.0421 mL 0.2106 mL 0.4212 mL 1.0530 mL
100 mM 0.0337 mL 0.1685 mL 0.3369 mL 0.8424 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Midodrine-d6 hydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Midodrine-d61188265-43-1Isotope-Labeled CompoundsAdrenergic ReceptorBeta ReceptorAdrenergic receptorα1-receptorHypotensionC2C12HL1HepG2Inhibitorinhibitorinhibit

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