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  4. CP-664511

CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM). CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases.

For research use only. We do not sell to patients.

CP-664511

CP-664511 Chemical Structure

CAS No. : 379692-00-9

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CP-664511 Related Antibodies

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αvβ1 αvβ3 αvβ5 αvβ6 αvβ8 α5β1 α1β1 α2β1 α4β1 α9β1 αIIbβ3 α4β7 αLβ2

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Description

CP-664511 is an orally active and potent α4β1 integrin antagonist with anti-inflammatory effects (IC50=0.52 nM). CP-664511 inhibits the interaction between α4β1 and vascular cell adhesion molecule-1 (VCAM-1), significantly reducing eosinophil infiltration into lung tissue. CP-664511 is promising for research of asthma and allergic airway diseases[1].

Molecular Weight

522.59

Formula

C28H34N4O6
CAS No.
SMILES

O=C(O)CCC1=CC([C@@H](NC(CC2=CC=C(NC(NC3=CC=CC=C3C)=O)C(OC)=C2)=O)CC(C)C)=NO1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP-664511 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP-664511379692-00-9CP664511CP 664511Integrinα4β1 integrinVCAM-1asthmaallergic airway diseasesInhibitorinhibitorinhibit

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