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Pathways Recommended:	PROTAC

Results for "

PROTAC

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Ligands for Target Protein for PROTAC (342) PROTAC Linkers (2993) PROTAC-Linker Conjugates for PAC (9) 17β-HSD (1) AAK1 (4) Acetyl-CoA Carboxylase (2) ADC Linker (210) ADC Payload (1) Adrenergic Receptor (2) Akt (23) Aldose Reductase (1) AMPK (1) Anaplastic lymphoma kinase (ALK) (18) Androgen Receptor (42) AP-1 (1) APC (2) Apoptosis (293) ASK1 (3) ATM/ATR (3) ATP Synthase (2) Aurora Kinase (17) Autophagy (219) Bacterial (2) Bcl-2 Family (24) BCL6 (6) Bcr-Abl (9) Biochemical Assay Reagents (9) Btk (32) c-Fms (1) c-Kit (1) c-Met/HGFR (11) c-Myc (13) Cadherin (1) CaMK (2) Cannabinoid Receptor (1) Casein Kinase (7) Caspase (8) CDK (70) Checkpoint Kinase (Chk) (2) CRM1 (2) Cyclic GMP-AMP Synthase (1) Cyclin G-associated Kinase (GAK) (2) Cyclophilin (4) Cytochrome P450 (7) Dengue Virus (4) Deubiquitinase (5) Dipeptidyl Peptidase (1) Discoidin Domain Receptor (2) DNA Alkylator/Crosslinker (1) DNA Methyltransferase (1) DNA/RNA Synthesis (9) Drug Derivative (1) Drug Intermediate (5) Drug Isomer (1) Drug-Linker Conjugates for ADC (1) E1/E2/E3 Enzyme (16) E3 Ligase Ligand-Linker Conjugates (671) Early 2 Factor (E2F) (2) EGFR (39) Endogenous Metabolite (4) Endothelin Receptor (1) Ephrin Receptor (3) Epigenetic Reader Domain (225) Epoxide Hydrolase (4) ERK (19) Estrogen Receptor/ERR (46) Eukaryotic Initiation Factor (eIF) (1) FAK (14) Fat Mass and Obesity-associated Protein (FTO) (2) Ferroptosis (11) FGFR (9) FKBP (22) Flavivirus (1) FLT3 (20) Fluorescent Dye (3) Fungal (1) GLP Receptor (2) Glutaminase (2) Glutathione Peroxidase (7) GSK-3 (2) HBV (4) HCV (2) HDAC (42) Hedgehog (1) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (7) Histone Acetyltransferase (10) Histone Demethylase (7) Histone Methyltransferase (34) HIV (7) HSP (5) IAP (9) IFNAR (4) IGF-1R (1) IKK (4) IKZF Family (4) Indoleamine 2,3-Dioxygenase (IDO) (5) Influenza Virus (1) Interleukin Related (7) IRAK (28) Isotope-Labeled Compounds (6) Itk (5) JAK (15) JNK (2) Keap1-Nrf2 (2) Kinesin (2) Leukotriene Receptor (3) Ligands for E3 Ligase (291) LIM Kinase (LIMK) (2) Liposome (6) LRRK2 (4) LYTACs (1) Macrophage migration inhibitory factor (MIF) (1) MAGL (2) MAP3K (1) MAP4K (13) MDM-2/p53 (18) MEK (6) MELK (1) METTL3 (5) MHC (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) Mitophagy (1) Mixed Lineage Kinase (3) MMP (1) MNK (2) Molecular Glues (10) Mps1 (4) mTOR (2) Na+/K+ ATPase (1) NAMPT (4) NF-κB (11) NOD-like Receptor (NLR) (1) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (1) Oxysterol-binding Protein-related Protein (ORP) (3) P-glycoprotein (1) p38 MAPK (11) PAK (2) PARP (20) PD-1/PD-L1 (11) PDGFR (2) PDI (1) PDK-1 (1) PERK (3) PGE synthase (1) Phosphatase (8) Phosphodiesterase (PDE) (1) PI3K (8) PI5P4K (1) PIKfyve (3) PIN1 (6) Polo-like Kinase (PLK) (2) Pregnane X Receptor (PXR) (9) Progesterone Receptor (1) Prostaglandin Receptor (2) PROTACs (956) Proteasome (1) PTEN (1) Pyroptosis (1) Raf (6) RANKL/RANK (1) RAR/RXR (1) Ras (46) Reactive Oxygen Species (ROS) (7) Reference Standards (6) RET (6) RIP kinase (8) ROR (2) ROS Kinase (2) Salt-inducible Kinase (SIK) (2) SARS-CoV (10) Ser/Thr Kinase (1) SF3B1 (1) SGK (4) SHP2 (3) Sirtuin (2) Small Interfering RNA (siRNA) (1) SNIPERs (6) SOS1 (18) Src (6) STAT (25) STING (11) SWI/SNF Complex (10) Syk (1) TAM Receptor (2) Target Protein Ligand-Linker Conjugates (66) Tau Protein (3) Telomerase (2) TGF-beta/Smad (2) TNF Receptor (5) Toll-like Receptor (TLR) (3) Transmembrane Glycoprotein (1) Trk Receptor (3) Tyrosinase (2) ULK (2) VEGFR (6) Virus Protease (7) WDR5 (8) Wee1 (4) Wnt (3) YAP (4) YTHDF (2) α-synuclein (3) β-catenin (3)
By Research Areas:	Cancer (5118) Cardiovascular Disease (9) Endocrinology (5) Infection (50) Inflammation/Immunology (97) Metabolic Disease (24) Neurological Disease (25)
Click Chemistry:	ADC Synthesis (55) TCO (52) DBCO (103) PROTAC Synthesis (802) Azide (484) BCN (34) Tetrazine (43) Alkynes (262)
Oligonucleotides:	Cosolvents (1) Pegylated Lipids (5) Emulsifiers (1) Bases (1)

5414

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

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Peptides

Natural
Products

Isotope-Labeled Compounds

975

Click Chemistry

Oligonucleotides

Targets Recommended: PROTAC Linkers PROTAC-Linker Conjugates for PAC Ligands for Target Protein for PROTAC

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139304

PROTAC Bcl-xL ligand-1	Ligands for Target Protein for PROTAC Bcl-2 Family	Cancer
PROTAC Bcl-xL ligand-1 is a ligand for Bcl-xL that can be used in the synthesis of PROTACs .

HY-156591

PROTAC MLKL Degrader-1	PROTACs Mixed Lineage Kinase	Others
PROTAC MLKL Degrader-1 (Compound 36) is a PROTAC degrader of MLKL, with a D_max ＞90%. PROTAC MLKL Degrader-1 contains modified CRBN ligands, linker and Lenalidomide (HY-A0003)-linker fragments. PROTAC MLKL Degrader-1 abrogates cell death in a TSZ model of necroptosis.

HY-149678

PROTAC eDHFR Degrader-1	PROTACs	Cancer
PROTAC eDHFR Degrader-1 is a PROTAC that is effective degradation of eDHFR-YFP, various POIs-including YFP and Luciferase .

HY-168311

PROTAC IRAK4 ligand-5	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-5 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). PROTAC IRAK4 ligand-5 can be utilized for the synthesis of KT-413 (HY-153368) .

HY-163152

PROTAC BRM degrader-1	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRM degrader-1 (compound 17) is a *PROTAC*-based BRM and BRG1 degrader, with DC₅₀ values of 93 pM and 4.9 nM, respectively .

HY-145073

PROTAC ER Degrader-10	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-10 is a potent PROTAC ER degrader and can be used for cancer research. PROTAC ER Degrader-10 is extracted from patent WO2021133886, example 36.

HY-159947

PROTAC BTK Degrader-11	PROTACs Btk	Cancer
PROTAC BTK Degrader-11 is a *PROTAC* degrader that can break down BTK, with a DC₅₀ of 1.7 nM. PROTAC BTK Degrader-11 can be used in cancer research. (Pink: target protein ligand (HY-159956); Black: linker; Blue: E3 ligase (HY-150839)) .

HY-157577

PROTAC(H-PGDS)-8	PROTACs Prostaglandin Receptor	Cardiovascular Disease
PROTAC(H-PGDS)-8 is a Hematopoietic prostaglandin D synthase (H-PGDS) PROTAC degrader, with a IC₅₀ of 0.14 μM .

HY-146368

PROTAC VEGFR-2 degrader-1	PROTACs VEGFR	Cancer
PROTAC VEGFR-2 degrader-1（PROTAC-1）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC₅₀> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC₅₀> 100 μM) .

HY-146369

PROTAC VEGFR-2 degrader-2	PROTACs VEGFR	Cancer
PROTAC VEGFR-2 degrader-2（PROTAC-4）, a PROTAC VEGFR-2 degrader, exhibits little VEGFR-2 inhibition (IC₅₀> 1 μM) and anti-proliferative activity against EA.hy926 cells (IC₅₀> 100μM) .

HY-168611

PROTAC IRAK4 ligand-4	Ligands for Target Protein for PROTAC IRAK	Cancer
PROTAC IRAK4 ligand-4 is a Ligand for Target Protein for PROTAC with antitumor activity. PROTAC IRAK4 ligand-4 can be used to synthesize PROTAC IRAK4 degrader-12 (HY-168586) .

HY-111846

PROTAC ERα Degrader-2 1 Publications Verification	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERα Degrader-2 (Compound 11) is a ERα PROTAC degrader. PROTAC ERα Degrader-2 significantly down-regulates the level of ERα in MCF-7 cells.(Pink: AR ligand (HY-43962), Blue: IAP Ligand (HY-177389), Black: Linker (HY-128833)) .

HY-145484

PROTAC IRAK4 ligand-3	Ligands for Target Protein for PROTAC	Cancer
PROTAC IRAK4 ligand-3 is a ligand of PROTAC KT-474 (HY-145483) that can be used in cancer research .

HY-168257

PROTAC SMARCA2 degrader-30	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2 degrader-30 (example 85) is a PROTAC SMARCA2 degrader with a DC₅₀ less than 100 nM in H1299 cells .

HY-169072

PROTAC MLKL Degrader-2	PROTACs Mixed Lineage Kinase	Cancer
PROTAC MLKL Degrader-2 (compound MP-1) is a PROTAC targeting MLKL (Mixed Lineage Kinase). PROTAC MLKL Degrader-2 is composed of PROTAC target protein ligand PROTAC MLKL Degrader-2 (HY-169072) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part) and PROTAC Linker N-Methylpiperazine (HY-78871) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is Thalidomide-N-methylpiperazine (HY-169074) ^{[1] ^.}

HY-112811

PROTAC CDK9 degrader-2	PROTACs CDK	Cancer
PROTAC CDK9 degrader-2 (compound 11c) is a potent and selective CDK9 degrader based on *PROTAC, with an IC₅₀* of 17 μM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC .

HY-163372

PROTAC HPK1 Degrader-1	PROTACs MAP4K	Cancer
PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC₅₀ value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC₅₀ value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide *HPK1-PROTAC* degrader, which provided a potential tool for further HPK1 investigation in TCR signaling .

HY-155393

PROTAC BRD4 Degrader-22	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-22 (Compd 44h) is a PROTAC-based BRD4 degrader, with a pDC₅₀ (MOLT4, 24 h) of 9.2 .

HY-168054

PROTAC K-Ras Degrader-3	PROTACs Ras	Cancer
PROTAC K-Ras Degrader-3 (compound 40) is a PROTAC degrader of K-Ras with a DC₅₀ of ≤ 1 nM against SW620 KRAS G12D, and a GI₅₀ of ≤ 10 nM against SW620 3D cell growth. PROTAC K-Ras Degrader-3 can be utilized in cancer research .

HY-135382A

PROTAC IRAK4 degrader-3	PROTACs IRAK	Inflammation/Immunology
PROTAC IRAK4 degrader-3 is a PROTAC-induced IRAK4 degrader based on von Hippel-Lindau .

HY-174920

PROTAC BRD4 Degrader-34	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-34 (Compound MZ2) is a selective BRD4 PROTAC degrader (pDC₅₀ = 8.4). PROTAC BRD4 Degrader-34 can induce BD2 degradation mediated by VHL. PROTAC BRD4 Degrader-34 can be used for research on cancer. (Pink: BRD4-BD2 Ligand (HY-78695); Blue: VHL Ligand (HY-125845); Black: Linker (HY-130524)) .

HY-168551

PROTAC ALK degrader-3	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
PROTAC ALK degrader-3 (4B) is an orally active ALK degrader based on PROTACs, which can effectively induce persistent degradation of ALK fusion protein in Karpas 299 cells and strong inhibition of downstream pathways,IC₅₀ is 119.33 nM. PROTAC ALK degrader-3 exhibits antitumor activity. (Structure Note: PINK, ALK Inhibitor (HY-15656); Blue, E3 (HY-W023573); Black, linker (HY-168552)) .

HY-161930

PROTAC GPX4 degrader-3	PROTACs Ferroptosis	Cancer
PROTAC GPX4 degrader-3 is a potent PROTAC GPX4 degrader with a DC₅₀ (24h) of 0.019 μM and an IC₅₀ of 0.024 μM in HT1080 cell .

HY-168037

PROTAC PIN1 degrader-1	PROTACs PIN1	Cancer
PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part) ^{[1] ^.}

HY-162106

PROTAC GPX4 degrader-2	Ferroptosis PROTACs Glutathione Peroxidase	Cancer
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC_{50, 48h} value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect .

HY-111866

PROTAC RIPK degrader-2 1 Publications Verification	PROTACs RIP kinase	Metabolic Disease Cancer
PROTAC RIPK degraders -2 is a non-peptide *PROTAC* based on von Hippel-Lindau and targets serine-threonine kinase RIPK2, which is highly selective to the degradation of RIPK2. PROTAC RIPK degrader-2 acts as an activator to increase cell death and activate ion channels in cancer cells. PROTAC RIPK degrader-2 also can inhibit protein interactions, such as receptors and ligands, involved in a variety of diseases, such as cancer and diabetes .

HY-173467

PROTAC MTP3 degrader-1	PROTACs c-Myc	Cancer
PROTAC MTP3 degrade-1 is a PROTAC based MYC degrader (Red: MYC inhibitor (HY-173469), black: linker (HY-W008296), Blue: E3 ligase ligand (HY-14658)) .

HY-149236

PROTAC GPX4 degrader-1	PROTACs Glutathione Peroxidase Ferroptosis	Cancer
PROTAC GPX4 degrader-1 (DC-2) is a PROTAC-based GPX4 degrader, with a DC₅₀ of 0.03 μM in HT1080 cells .

HY-158142

PROTAC TYK2 degrader-1	PROTACs JAK	Cancer
PROTAC TYK2 degrader-1 (CPD-155) is a PROTAC targeting degrader to TYK2 with D_max >60%. (Structure Note: PINK, TYK2 ligand 1 (HY-158340); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)

HY-163582

PROTAC SOS1 degrader-7	PROTACs SOS1 Ras	Cancer
PROTAC SOS1 degrader-7 (Example 15) is a SOS1 PROTAC degrader. PROTAC SOS1 degrader-7 has anti-tumor activity . (Pink: SOS1 ligand (HY-163583); Black: linker (HY-163584); Blue: E3 ligase ligand (HY-W454906)) .

HY-176449

PROTAC BRD4 Degrader-32	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-32 (Compound 22) is a BRD4 *PROTAC* degrader (DC₅₀: 0.20 nM). PROTAC BRD4 Degrader-32 connects the BRD4-binding domain and CRBN-binding domain through a unique carbon-carbon linked linker to form a ternary complex, inducing ubiquitination of BRD4 for proteasomal degradation. PROTAC BRD4 Degrader-32 is promising for research of BRD4-related cancers (such as hematological malignancies). (Pink: GSK1324726A (HY-13960); Black: linker (HY-176450); Blue: Lenalidomide-5-Br (HY-W072954)) .

HY-156244

PROTAC GDI2 Degrader-1	PROTACs	Cancer
PROTAC GDI2 Degrader-1 (compound 21) is a potent PROTAC GDI2 degrader. PROTAC GDI2 Degrader-1 exhibits excellent in vivo antitumor activity in the GDI2-overexpressing pancreatic xenograft models .

HY-135309

PROTAC ER Degrader-4	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ER Degrader-4 is a von Hippel-Lindau-based PROATC estrogen receptor (ER) degrader, binding to ER with an IC50 of 0.8 nM. PROTAC ER Degrader-4 induces ER degradation in MCF-7 cells with an IC₅₀ of 0.3 nM .

HY-133131

PROTAC BRD4 Degrader-1	PROTACs Epigenetic Reader Domain	Cancer
PROTAC BRD4 Degrader-1 is a PROTAC connected by ligands for Cereblon and BRD4 with an IC₅₀ of 41.8 nM against BRD4 BD1. PROTAC BRD4 Degrader-1 can effectively degrade BRD4 protein and suppress c-Myc expression .

HY-135382

PROTAC IRAK4 degrader-2	PROTACs IRAK	Inflammation/Immunology Cancer
PROTAC IRAK4 degrader-2 (Compound 9) is a PROTAC-based IRAK4 degrader that affords potent IRAK4 degradation with a DC₅₀ in peripheral blood mononuclear cells (PBMCs) cells of 151 nM. PROTAC IRAK4 degrader-2 induce a reduction of IRAK4 protein levels with a DC₅₀ of 36 nM in PBMC cells. PROTAC IRAK4 degrader-2 also leads to the inhibition of multiple cytokines in PBMCs .

HY-128841

PROTAC MDM2 Degrader-2 1 Publications Verification	PROTACs MDM-2/p53 E1/E2/E3 Enzyme	Cancer
PROTAC MDM2 Degrader-2 is an MDM2 PROTAC degrader. PROTAC MDM2 Degrader-2 can induce the self-ubiquitination and degradation of MDM2, thereby upregulating the level of p53 protein. PROTAC MDM2 Degrader-2 has anti-tumor activity and can be used in the study of cancer . (Blue: MDM2 ligand (HY-128836); Black: linker (HY-128833))

HY-153023

PROTAC STAT3 degrader-2	PROTACs STAT	Cancer
PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC₅₀ of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research . PROTAC STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-174453

PROTAC ERα Degrader-12	PROTACs Estrogen Receptor/ERR Apoptosis	Cancer
PROTAC ERα Degrader-12 is a potent and selective Erα PROTAC degrader. PROTAC ERα Degrader-12 has antiproliferative effects in multiple breast cancer cell lines with wild-type or mutant ERα. PROTAC ERα Degrader-12 can halt the cell cycle and induce cell apoptosis. PROTAC ERα Degrader-12 exhibits excellent antitumor and ERα degradation activity. PROTAC ERα Degrader-12 can be used for research on breast cancer. (Pink: ER ligand-11 (HY-174475); Blue: VHL ligand (HY-112078); Black: Linker (HY-W088749); VHL ligand + Linker ( HY-W998310)) .

HY-135345

PROTAC FKBP Degrader-3 1 Publications Verification	PROTACs FKBP	Cancer
PROTAC FKBP Degrader-3 is a PROTAC that comprises a FKBP ligand binding group, a linker and an von Hippel-Lindau binding group. PROTAC FKBP Degrader-3 is a potent FKBP degrader .

HY-129939

PROTAC BRD4 ligand-1	Epigenetic Reader Domain Ligands for Target Protein for PROTAC	Cancer
PROTAC BRD4 ligand-1 is a potent BET inhibitor and a ligand for target BRD4 protein for PROTACT GNE-987 (HY-129937A) .

HY-146349

PROTAC EGFR degrader 4	PROTACs EGFR Autophagy	Cancer
PROTAC EGFR degrader 4 is a potent *PROTAC* targeting mutant *EGFR*.PROTAC EGFR degrader 4 induces EGFR ^del19 and EGFR ^L858R/T790M degradation with DC₅₀s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC₅₀s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy .

HY-139185

PROTAC ERRα Degrader-3 1 Publications Verification	PROTACs Estrogen Receptor/ERR	Cancer
PROTAC ERRα Degrader-3 is a potent and selective ERRα degrader based on von Hippel-Lindau ligand. PROTAC ERRα Degrader-3 is capable of specifically degrading ERRα protein by >80% at a concentration of 30 nM. PROTAC ERRα Degrader-3 is inactive against ERRβ and ERRγ proteins .

HY-164365

PROTAC K-Ras Degrader-2	PROTACs Ras	Cancer
PROTAC K-Ras degrader-2 (compound 48) is a pan-KRAS-mutant PROTAC degrader with an IC₅₀ of ≤200 nM for KRAS G12V/RAF1. PROTAC K-Ras degrader-2 degrades SW620 KRAS G12D with a DC₅₀ of ≤200 nM. PROTAC K-Ras degrader-2 inhibits cell growth of SW620 3D cell with an IC₅₀ of ≤20 nM. (Pink: KRAS inhibitor-30 (HY-164366)) .

HY-174233

PROTAC SARS-CoV-2 Degrader-1	PROTACs SARS-CoV Virus Protease	Infection
PROTAC SARS-CoV-2 Degrader-1 (Compound LLP019) is a SARS-CoV-2 M ^Pro *PROTAC* degrader with a DC₅₀ value of 4.7 μM. PROTAC SARS-CoV-2 Degrader-1 induces M ^Pro ubiquitination and proteasomal degradation to inhibit SARS-CoV-2 replication. PROTAC SARS-CoV-2 Degrader-1 is promising for research of COVID-19 and related coronavirus infections. (Pink: DH03 (HY-32717); Black: linker (HY-42149); Blue: Thalidomide-4-O-CH2-COO(t-Bu) (HY-42771) .

HY-129966

PROTAC IRAK4 degrader-1 1 Publications Verification	PROTACs IRAK	Cancer
PROTAC IRAK4 degrader-1 (compound I-210) is a Cereblon-based IRAK4 PROTAC. PROTAC IRAK4 degrader-1 is composed of IRAK4 ligand (red part) PROTAC IRAK4 ligand-1 (HY-129967), E3 ligase ligand (blue part) Pomalidomide (HY-10984), and PROTAC linker (black part) AM-Imidazole-PA-Boc (HY-129968) .

HY-173369

PROTAC MAGL degrader-1	PROTACs MAGL	Cancer
PROTAC MAGL degrader-1 is an orally active PROTAC agent that simultaneously targets monoacylglycerol lipase (MAGL) and E3 ubiquitin ligase MDM2. PROTAC MAGL degrader-1 degrades MAGL and inhibits the binding of MDM2 to p53. PROTAC MAGL degrader-1 can partially penetrate the blood-brain barrier (BBB). PROTAC MAGL degrader-1 induces glioblastoma stem cells (GSCs) apoptosis. (E3 ligase ligand: HY-128837; target protein ligand + linker: HY-173370; target protein inhibitor: HY-15249) .

HY-162835

PROTAC SMARCA2/4-degrader-28	PROTACs Epigenetic Reader Domain	Cancer
PROTAC SMARCA2/4-degrader-28 (PROTAC 1) is a *PROTAC*-based partial degrader of SMARCA2 and SMARCA4(Bliue: CRL2 ^VHL ligand (S,R,S)-AHPC (HY-125845); Black: linker (HY-159680); Pink: a SMARCA-BD ligand (+)-JQ-1 (HY-13030)) .

HY-161173

PROTAC SOS1 degrader-5	PROTACs Ras	Cancer
PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC₅₀ of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC₅₀ of 5 nM .

HY-156566

PROTAC BRD4 Degrader-21	Epigenetic Reader Domain PROTACs	Cancer
PROTAC BRD4 Degrader-21 (Comp 74) is a PROTAC degrader of BRD4. PROTAC BRD4 Degrader-21 displays significant tumor growth inhibition in tumor -bearing xenograft models in mice and can be used for anticancer research .

HY-161536

PROTAC EGFR degrader 9	PROTACs EGFR Apoptosis	Cancer
PROTAC EGFR degrader 9 (Compound C6) is an orally active CRBN-based PROTAC EGFR degrader. PROTAC EGFR degrader 9 exhibits a DC₅₀ of 10.2 nM and a K_d of 240.2 nM against EGFR ^{L858R/T790M/C797S}. PROTAC EGFR degrader 9 exhibits potent degradation activity against various EGFR mutants, while sparing the EGFRWT. (Blue: CRBN ligand (HY-A0003), Black: linker (HY-161613); Pink: EGFR inhibitor (HY-161537)) .

Cat. No.	Product Name

HY-L222

PROTAC Linkers Library

0 compounds

Linkers play a necessary role in the physicochemical properties and biological activity of the bifunctional molecule. These linkers are not a simply connection of two functional modules together, but its design and nature directly affect the stability, activity, selectivity, pharmacokinetics, and ultimately the therapeutic efficacy of the entire molecule. The length of the linker determines the extent of interaction between the two ligands and thus the maximum activity of the PROTAC molecule.

MCE has collected 0 PROTAC Linkers can be used for the design and synthesis of bifunctional molecules.

HY-L151

PROTAC Library

416 compounds

PROTACs (Proteolysis-targeting chimeras) is a class of molecules that utilize ubiquitin-proteasome system (UPS) to ubiquitinate and degrade target proteins. The PROTACs molecule consists of two ligands joined by a linker. The one-to-one interaction between PROTACs and target proteins determines the high efficiency of PROTACs, making it a potential molecule for targeted protein degradation (TPD) therapy.

MCE supplies a unique collection of 416 PROTACs that effectively degrade target proteins with more powerful screening capability. MCE PROTAC Library is a useful tool for signal pathway research, protein degradation therapy research, drug discovery and drug repurposing, etc.

HY-L129

Target Protein Ligand Library

69 compounds

Proteolysis-targeting chimera (PROTAC) has been developed to be a useful technology for targeted protein degradation. PROTACs consist of a ligand for E3 ligase (E3 ligase binder), a linker and a ligand (mostly small-molecule inhibitor) for protein of interest（target binder）. Upon binding to the target protein, the PROTACs can recruit E3 for target protein ubiquitination, which is subjected to proteasome-mediated degradation. Therefore, PROTACs execute their functions by degrading the target proteins rather than inhibiting them, which has a great superiority in overcoming resistance caused by target mutation or overexpression. To date, PROTAC technology has been applied to a variety of targets, including AR, ER, BTK, BET, and BCR-ABL to overcome resistance.

MCE carefully prepared a unique collection of 69 ligands for target proteins, which have been reported to be used in PROTAC design. MCE Target Protein Ligand Library is a useful tool for PROTAC development.

HY-L128

E3 Ligase Ligand Library

94 compounds

Although there are more than 600 E3 ubiquitin ligases, only several with small molecule ligands have been used for designing PROTACs, including Skp1-Cullin-F box complex containing Hrt1 (SCF), Von Hippel-Lindau tumor suppressor (VHL), Cereblon (CRBN), inhibitor of apoptosis proteins (IAPs), and mouse double minute 2 homolog (MDM2).

MCE carefully prepared a unique collection of 94 ligands for E3 ligase, which have been reported to be used in PROTAC design. MCE E3 ligase ligand library is a useful tool for PROTAC development.

HY-L137

Molecular Glue Compound Library

74 compounds

Targeted protein degradation(TPD) is a novel and promising approach to new drug discovery and development. It shows great potential for treating diseases with “undruggable” pathogenic protein targets and for overcoming drug resistance. Molecular glues and PROTACs are both targeted protein degraders that have attracted the most attention.

Molecular glues are small molecular degraders that mainly induce novel interaction between an E3 ligase and a target protein to form a ternary complex, leading to protein ubiquitination and subsequent proteasome degradation. Compared with PROTACs, molecular glues generally possess more favorable drug-like properties, such as lower MW, higher cell permeability, and better oral absorption. Molecular glues are emerging as a promising new therapeutic strategy.

MCE supplies a unique collection of 74 molecular glues which target various proteins. MCE Molecular Glue Compound Library is a useful tool to conduct scientific research and disease mechanism study.

HY-L918

Molecular Glue-like Compound Library

318 compounds

Targeted Protein Degradation (TPD) is a novel and promising approach to drug development. It shows great potential for targeting proteins traditionally considered "undruggable" due to the lack of enzymatic function and absence of binding sites by tagging them for degradation or recruiting natural degradation mechanisms.

Molecular glues are a type of small-molecule degraders that primarily induce novel interactions between E3 ubiquitin ligases and target proteins, forming ternary complexes that lead to protein ubiquitination and subsequent proteasomal degradation. Compared with PROTACs, molecular glues generally have lower molecular weights, higher cell permeability, and better drug-like properties. Additionally, the design of molecular glues is relatively simple, without the requirements for complex linkers and ligand optimization. As a result, molecular glues have gradually emerged as a promising therapeutic approach for various diseases.

Multiple types of molecular glues have been reported previously. Analysis of co-crystal complex structures reveals that CRBN-related molecular glues are more versatile. Therefore, MCE researchers select active molecules related to these targets as probes for artificial intelligence (AI) screening.Subsequently, molecular docking technology was used to verify whether the screened molecules retained the key pharmacophore features. Ultimately, we obtained 320 molecular glue analogs, and these compounds serve as powerful tools for the research of molecular glues.

Cat. No.	Product Name	Type

HY-D2336

PROTAC Aster-A degrader-1	Fluorescent Dyes/Probes
PROTAC Aster-A degrader-1 (compound NGF3) is a degrader of the sterol transport protein Aster-A. PROTAC Aster-A degrader-1 can be used as a fluorescence probe. (Red: Aster-A inhibitor, black: linker, Blue: E3 ligase ligand) .

HY-140938A

(Rac)-Biotin-PEG3-oxyamine hydrochloride	Fluorescent Dyes/Probes
(Rac)-Biotin-PEG3-oxyamine hydrochloride is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-141085

Carboxyfluorescein-PEG12-NHS	Fluorescent Dyes/Probes
Carboxyfluorescein-PEG12-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-D2420

Biotin-PEG5-Mal	Fluorescent Dyes/Probes
Biotin-PEG5-Mal is a PROTAC linker, belonging to the PEG class. It can be used for the synthesis of PROTAC molecules .

HY-133376

DBCO-NHCO-PEG12-biotin	Dyes
DBCO-NHCO-PEG12-biotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . DBCO-NHCO-PEG12-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

HY-130768

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid

Fluorescent Dyes/Probes

N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a PEG-based PROTAC linker which contains azide, fluorescein and carboxylic acid moieties. N-(Azido-PEG3)-N-Fluorescein-PEG3-acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Cat. No.	Product Name	Type

HY-W023573

5-Aminothalidomide	Biochemical Assay Reagents
5-Aminothalidomide is an E3 ligase ligand used in *PROTAC* technology. 5-Aminothalidomide can be used to synthesize various *PROTACs, such as the PROTAC* BRD9 Degrader-7 (HY-155361).

HY-140700

m-PEG-NHS ester (MW 20000) mPEG-SC (MW 20000); mPEG-Succinimidyl ester (MW 20000)	Drug Delivery
m-PEG-NHS ester (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140699

m-PEG-NHS ester (MW 10000) mPEG-SC (MW 10000); mPEG-Succinimidyl ester (MW 10000)	Drug Delivery
m-PEG-NHS ester (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140698

m-PEG-NHS ester (MW 5000) mPEG-SC (MW 5000); mPEG-Succinimidyl ester (MW 5000)	Drug Delivery
m-PEG-NHS ester (MW 5000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140736

DSPE-PEG-Biotin, MW 2000 DSPE-PEG(2000) Biotin	Drug Delivery
DSPE-PEG-Biotin, MW 2000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140679

mPEG-amine (MW 20000) mPEG-NH2 (MW 20000)	Drug Delivery
m-PEG-NH2 (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140736A

DSPE-PEG-Biotin, MW 1000	Drug Delivery
DSPE-PEG-Biotin, MW 1000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140736B

DSPE-PEG-Biotin, MW 5000	Drug Delivery
DSPE-PEG-Biotin, MW 5000 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-163790

Desthiobiotin-PEG3-sulfo-Maleimide	Biochemical Assay Reagents
Desthiobiotin-PEG3-sulfo-Maleimide is a PEG linker can be used in the synthesis of PROTACs .

HY-140956

DSPE-PEG8-Mal	Drug Delivery
DSPE-PEG8-Mal is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140675

mPEG-amine (MW 1000) mPEG-NH2 (MW 1000)	Drug Delivery
m-PEG-NH2 (MW 1000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-136158A

6-Maleimidocaproic acid sulfo-NHS sodium Sulfo-EMCS	Drug Delivery
6-Maleimidocaproic acid sulfo-NHS (Sulfo-EMCS) sodium is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140676

mPEG-amine (MW 2000) mPEG-NH2 (MW 2000)	Drug Delivery
mPEG-amine (mPEG-NH2) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140678

mPEG-amine (MW 10000) mPEG-NH2 (MW 10000)	Drug Delivery
mPEG-amine (mPEG-NH2) (MW 10000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140649

PEG-bis-amine (MW 20000) Poly(ethylene glycol)-bis-amine (MW 20000)	Drug Delivery
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 20000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140646

PEG-bis-amine (MW 2000) Poly(ethylene glycol)-bis-amine (MW 2000)	Drug Delivery
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-140647

PEG-bis-amine (MW 3400) Poly(ethylene glycol)-bis-amine (MW 3400)	Drug Delivery
PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-174925

Thalidomide-O-PEG3-COOH	Drug Delivery
Thalidomide-O-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology .

HY-141658

Pomalidomide-PEG6-C2-COOH Pomalidomide-PEG6-COOH	Drug Delivery
Pomalidomide-PEG6-C2-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide (HY-10984) based cereblon ligand and 6-unit PEG linker used in PROTAC technology .

Cat. No.	Product Name	Target	Research Area

HY-P5819

xStAx-VHLL 3 Publications Verification	Wnt PROTACs β-catenin	Cancer
xStAx-VHLL is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-P5819A

xStAx-VHLL TFA 3 Publications Verification	PROTACs β-catenin Wnt	Cancer
xStAx-VHLL TFA is a β-catenin PROTAC degrader that promotes ubiquitination and proteasome degradation of β-catenin. xStAx-VHLL TFA inhibits the Wnt/β-catenin signaling pathway. xStAx-VHLL TFA can inhibit the proliferation of colon cancer cells and has anti-tumor activity .

HY-162946

Alkyne-P60	Ligands for Target Protein for PROTAC	Cancer
Alkyne-P60 is a potent 15-mer peptide inhibitor of Foxp3. Alkyne-P60 can bind with Foxp3, hinder its nuclear translocation, and diminish Foxp3-mediated inhibition of NFKB and NFAT functions. Alkyne-P60 is a ligand for target protein for PROTAC (HY-162943).

HY-P10899

ETTAC-2	TGF-beta/Smad PROTACs	Endocrinology
ETTAC-2 is a LRG1 PROTAC degrader. ETTAC-2 promotes ubiquitination and degradation of LRG1 (DC₅₀ of 8.38 µM). ETTAC-2 inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated proteins. ETTAC-2 attenuates the progression of renal fibrosis .

HY-P10446

TAT-PiET-PROTAC	Epigenetic Reader Domain PROTACs	Cancer
TAT-PiET-PROTAC is a proteolysis-targeting chimera (PROTAC)-modified TAT-PiET (HY-P10445), which is a cell-penetrating peptide targeting the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC can reduce BRD4 and JMJD6 levels and inhibit cell proliferation. TAT-PiET-PROTAC also resists the endocrine resistance of ERα-positive breast cancer cells. TAT-PiET-PROTAC can be used for the research of cancer, such as breast cancer .

HY-P10981

ErbB2 peptide	PI3K Ligands for E3 Ligase	Cancer
ErbB2 peptide is a peptide ligand of E3 ubiquitin ligase targeting PI3K for peptide PROTACs .

HY-169235

DHHC3 ligand 1	Ligands for Target Protein for PROTAC	Cancer
DHHC3 degrader 1 is a PROTAC target protein ligand that is used to synthesize PCC16 chloride (HY-169232) .

HY-P5559

ND1-YL2	PROTACs	Cancer
ND1-YL2 is a *PROTAC* that selectively degrades SRC-1 via the N-degron pathway. ND1-YL2 significantly inhibits cancer invasion and migration in vitro and in vivo. ND1-YL2 can be used in cancer research .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W001958

Monomethyl octanoate Suberic acid monomethyl ester	Classification of Application Fields Ketones, Aldehydes, Acids Source classification Metabolic Disease Endogenous metabolite Disease Research Fields	Biochemical Assay Reagents PROTAC Linkers
Monomethyl octanoate (Suberic acid monomethyl ester) is an ester product. Monomethyl octanoate is a PROTAC linker that can be used in the synthesis of PROTACs, DDD2 (HY-176261) .

HY-W034918

Docosanedioic acid	other families Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Cancer	ADC Linker PROTAC Linkers
Docosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Docosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.

HY-107608

Leukotriene B4 4 Publications Verification LTB4; 5(S),12(R)-DiHETE	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Source classification Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Inflammation/Immunology Disease Research Fields Cardiovascular System Disorder	Endogenous Metabolite PROTAC Linkers Leukotriene Receptor
Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W034595

Eicosanedioic acid	Microorganisms Source classification	ADC Linker PROTAC Linkers
Eicosanedioic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Eicosanedioic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis

HY-W024365

3-tert-Butyl-4-methoxyphenol	Monophenols Source classification Jatropha curcas Linn. Phenols Euphorbiaceae Plants	PROTAC Linkers
3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-W010549R

2-Methylcyclohexanone (Standard)	Ketones, Aldehydes, Acids Source classification Endogenous metabolite	Reference Standards Endogenous Metabolite Biochemical Assay Reagents Fungal
3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

HY-W024365R

3-tert-Butyl-4-methoxyphenol (Standard)	Monophenols Source classification Jatropha curcas Linn. Phenols Euphorbiaceae Plants	PROTAC Linkers Reference Standards
3-tert-Butyl-4-methoxyphenol (Standard) is the analytical standard of 3-tert-Butyl-4-methoxyphenol. This product is intended for research and analytical applications. 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system .

Cat. No.	Product Name	Chemical Structure

HY-A0023AS2

Alogliptin-13C,d3 benzoate
Sulfo DBCO-PEG4-Maleimide TEA is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-107608S

Leukotriene B4-d4
Leukotriene B4-d₄ is the deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-126534S

Abemaciclib metabolite M18-d8
Abemaciclib metabolite M18-d₈ is the deuterium labeled Abemaciclib metabolite M18. Abemaciclib metabolite M18 (LSN3106729), the metabolite of Abemaciclib (HY-16297A), is a CDK inhibitor with antitumor activity. Abemaciclib metabolite M18 and a CRBN ligand have been used to design PROTAC CDK4/6 degrader .

HY-40171S

NH2-C2-NH-Boc-d4
NH2-C2-NH-Boc-d₄ is the deuterium labeled NH2-C2-NH-Boc . NH2-C2-NH-Boc (PROTAC Linker 22) is a alkyl chain-based PROTAC linker can be used in the synthesis of PROTACs .

HY-107608S1

Leukotriene B4-d5
Leukotriene B4-d₅ (LTB4-d₅) is deuterium labeled Leukotriene B4. Leukotriene B4 (LTB4) is known as one of the most potent chemoattractants and activators of leukocytes and is involved in inflammatory diseases. Leukotriene B4 is also an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs .

HY-W743931

2-Azidoethanol-d4

2-Azidoethanol-d₄ is the deuterium labeled Azido-PEG1 (HY-138461). Azido-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG1 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-140346AS

L-Azidohomoalanine-1,2,3,4-13C4 hydrochloride

L-Azidohomoalanine-1,2,3,4- ¹³C₄ (hydrochloride) is the ¹³C- and ¹⁵N-labeled L-Azidohomoalanine hydrochloride. L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs . L-Azidohomoalanine-1,2,3,4-13C4 (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-170126S

9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d3 Maleate
9-Amino-1,2,3,4-tetrahydroacridin-1-ol-d₃ Maleate is the deuterium labeled CRBN ligand-74 (HY-170126). CRBN ligand-74 is a CRBN-type E3 ubiquitin ligase ligand that can be used to prepare PROTAC.

HY-13001S

Quizartinib-d8

Quizartinib-d₈ (AC220-d₈) is deuterium labeled Quizartinib. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a K_d of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC₅₀s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis .

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