2. PROTAC
  3. PROTAC Linkers
  4. Propargyl-PEG5-OH

Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Propargyl-PEG5-OH Chemical Structure

Propargyl-PEG5-OH Chemical Structure

CAS No. : 1036204-60-0

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250 mg In-stock
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Based on 1 publication(s) in Google Scholar

Propargyl-PEG5-OH Related Antibodies

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Description

Propargyl-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG5-OH is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target[1]

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Propargyl-PEG5-OH Related Antibodies
Molecular Weight

276.33

Formula

C13H24O6
CAS No.
Appearance

Liquid (Density: 1.078 g/cm3)

Color

Colorless to light yellow

SMILES

OCCOCCOCCOCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (361.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6189 mL 18.0943 mL 36.1886 mL
5 mM 0.7238 mL 3.6189 mL 7.2377 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥97.0%

SDS (393 KB)

COA (239 KB) HNMR (111 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6189 mL 18.0943 mL 36.1886 mL 90.4715 mL
5 mM 0.7238 mL 3.6189 mL 7.2377 mL 18.0943 mL
10 mM 0.3619 mL 1.8094 mL 3.6189 mL 9.0472 mL
15 mM 0.2413 mL 1.2063 mL 2.4126 mL 6.0314 mL
20 mM 0.1809 mL 0.9047 mL 1.8094 mL 4.5236 mL
25 mM 0.1448 mL 0.7238 mL 1.4475 mL 3.6189 mL
30 mM 0.1206 mL 0.6031 mL 1.2063 mL 3.0157 mL
40 mM 0.0905 mL 0.4524 mL 0.9047 mL 2.2618 mL
50 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8094 mL
60 mM 0.0603 mL 0.3016 mL 0.6031 mL 1.5079 mL
80 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1309 mL
100 mM 0.0362 mL 0.1809 mL 0.3619 mL 0.9047 mL
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Propargyl-PEG5-OH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Propargyl-PEG5-OH1036204-60-0PROTAC LinkersPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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