2. PROTAC
  3. PROTAC Linkers
  4. SMPH Crosslinker

SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

SMPH Crosslinker

SMPH Crosslinker Chemical Structure

CAS No. : 367927-39-7

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Based on 1 publication(s) in Google Scholar

SMPH Crosslinker Related Antibodies

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms
PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

  • Biological Activity

  • Purity & Documentation

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Description

SMPH Crosslinker is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

Alkyl/ether

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SMPH Crosslinker Related Antibodies
Molecular Weight

379.36

Formula

C17H21N3O7
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(CCCCCNC(CCN1C(C=CC1=O)=O)=O)ON2C(CCC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (131.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6360 mL 13.1801 mL 26.3602 mL
5 mM 0.5272 mL 2.6360 mL 5.2720 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6360 mL 13.1801 mL 26.3602 mL 65.9005 mL
5 mM 0.5272 mL 2.6360 mL 5.2720 mL 13.1801 mL
10 mM 0.2636 mL 1.3180 mL 2.6360 mL 6.5900 mL
15 mM 0.1757 mL 0.8787 mL 1.7573 mL 4.3934 mL
20 mM 0.1318 mL 0.6590 mL 1.3180 mL 3.2950 mL
25 mM 0.1054 mL 0.5272 mL 1.0544 mL 2.6360 mL
30 mM 0.0879 mL 0.4393 mL 0.8787 mL 2.1967 mL
40 mM 0.0659 mL 0.3295 mL 0.6590 mL 1.6475 mL
50 mM 0.0527 mL 0.2636 mL 0.5272 mL 1.3180 mL
60 mM 0.0439 mL 0.2197 mL 0.4393 mL 1.0983 mL
80 mM 0.0330 mL 0.1648 mL 0.3295 mL 0.8238 mL
100 mM 0.0264 mL 0.1318 mL 0.2636 mL 0.6590 mL
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SMPH Crosslinker Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SMPH Crosslinker367927-39-7PROTAC LinkersInhibitorinhibitorinhibit

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