Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride

Cat. No.: HY-160244 Purity: 98.08%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride is the Pomalidomide (HY-10984)-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride can be connected to the ligand for protein by a linker to form PROTAC.

For research use only. We do not sell to patients.

Pomalidomide 5'-piperazine-4-methylpiperidine dihydrochloride Chemical Structure

CAS No. : 2758431-93-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms

von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

Biological Activity
Purity & Documentation
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Description

IC₅₀ & Target

Cereblon

Molecular Weight

512.43

Formula

C₂₃H₃₁Cl₂N₅O₄

CAS No.

2758431-93-3

Appearance

Solid

Color

Light yellow to brown

SMILES

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(CC5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (97.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9515 mL	9.7574 mL	19.5149 mL
5 mM	0.3903 mL	1.9515 mL	3.9030 mL
10 mM	0.1951 mL	0.9757 mL	1.9515 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.08%

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Data Sheet (242 KB) SDS (252 KB)

COA (248 KB) HNMR (269 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9515 mL	9.7574 mL	19.5149 mL	48.7872 mL
	5 mM	0.3903 mL	1.9515 mL	3.9030 mL	9.7574 mL
	10 mM	0.1951 mL	0.9757 mL	1.9515 mL	4.8787 mL
	15 mM	0.1301 mL	0.6505 mL	1.3010 mL	3.2525 mL
	20 mM	0.0976 mL	0.4879 mL	0.9757 mL	2.4394 mL
	25 mM	0.0781 mL	0.3903 mL	0.7806 mL	1.9515 mL
	30 mM	0.0650 mL	0.3252 mL	0.6505 mL	1.6262 mL
	40 mM	0.0488 mL	0.2439 mL	0.4879 mL	1.2197 mL
	50 mM	0.0390 mL	0.1951 mL	0.3903 mL	0.9757 mL
	60 mM	0.0325 mL	0.1626 mL	0.3252 mL	0.8131 mL
	80 mM	0.0244 mL	0.1220 mL	0.2439 mL	0.6098 mL