2. Cell Cycle/DNA Damage PROTAC
  3. Polo-like Kinase (PLK) Ligands for Target Protein for PROTAC
  4. dTAG Targeting Ligand 1

dTAG Targeting Ligand 1 (SUBSTITUTE SHEET 245) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). dTAG Targeting Ligand 1 can be used for synthesis PROTACs.

For research use only. We do not sell to patients.

dTAG Targeting Ligand 1

dTAG Targeting Ligand 1 Chemical Structure

CAS No. : 755039-56-6

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dTAG Targeting Ligand 1 Related Antibodies

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Description

dTAG Targeting Ligand 1 (SUBSTITUTE SHEET 245) is a PROTAC target protein ligand (Ligand for Target Protein for PROTAC). dTAG Targeting Ligand 1 can be used for synthesis PROTACs[1].

Molecular Weight

425.48

Formula

C22H27N5O4
CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C1[C@@H](CC)N(C2CCCC2)C3=NC(NC4=C(OC)C=C(C=C4)C(O)=O)=NC=C3N1C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (23.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3503 mL 11.7514 mL 23.5029 mL
5 mM 0.4701 mL 2.3503 mL 4.7006 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (255 KB) HNMR (119 KB) MS (306 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3503 mL 11.7514 mL 23.5029 mL 58.7572 mL
5 mM 0.4701 mL 2.3503 mL 4.7006 mL 11.7514 mL
10 mM 0.2350 mL 1.1751 mL 2.3503 mL 5.8757 mL
15 mM 0.1567 mL 0.7834 mL 1.5669 mL 3.9171 mL
20 mM 0.1175 mL 0.5876 mL 1.1751 mL 2.9379 mL
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dTAG Targeting Ligand 1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

dTAG Targeting Ligand 1755039-56-6dTAG Targeting Ligand1dTAG Targeting Ligand-1Polo-like Kinase (PLK)Ligands for Target Protein for PROTACTarget Protein-binding MoietyPROTAC target protein ligandInhibitorinhibitorinhibit

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