Mal-PEG8-NHS ester

Name: Mal-PEG8-NHS ester
Brand: MedChemExpress
SKU: HY-126887
Rating: 4.5 (1 reviews)

Cat. No.: HY-126887 Purity: 98.96%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Mal-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Mal-PEG8-NHS ester Chemical Structure

CAS No. : 2055033-05-9

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	Get quote
10 g	Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Mal-PEG8-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

618.63

Formula

C₂₇H₄₂N₂O₁₄

CAS No.

2055033-05-9

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCOCCOCCN2C(C=CC2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (161.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6165 mL	8.0824 mL	16.1648 mL
5 mM	0.3233 mL	1.6165 mL	3.2329 mL
10 mM	0.1616 mL	0.8082 mL	1.6165 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.96%

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Data Sheet (247 KB) SDS (393 KB)

COA (255 KB) HNMR (258 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6165 mL	8.0824 mL	16.1648 mL	40.4119 mL
	5 mM	0.3233 mL	1.6165 mL	3.2330 mL	8.0824 mL
	10 mM	0.1616 mL	0.8082 mL	1.6165 mL	4.0412 mL
	15 mM	0.1078 mL	0.5388 mL	1.0777 mL	2.6941 mL
	20 mM	0.0808 mL	0.4041 mL	0.8082 mL	2.0206 mL
	25 mM	0.0647 mL	0.3233 mL	0.6466 mL	1.6165 mL
	30 mM	0.0539 mL	0.2694 mL	0.5388 mL	1.3471 mL
	40 mM	0.0404 mL	0.2021 mL	0.4041 mL	1.0103 mL
	50 mM	0.0323 mL	0.1616 mL	0.3233 mL	0.8082 mL
	60 mM	0.0269 mL	0.1347 mL	0.2694 mL	0.6735 mL
	80 mM	0.0202 mL	0.1010 mL	0.2021 mL	0.5051 mL
	100 mM	0.0162 mL	0.0808 mL	0.1616 mL	0.4041 mL