Fluorescein-PEG3-amine

Name: Fluorescein-PEG3-amine
Brand: MedChemExpress
SKU: HY-141080
Rating: 4.5 (1 reviews)

Cat. No.: HY-141080: Data Sheet Handling Instructions
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Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fluorescein-PEG3-amine Chemical Structure

CAS No. : 1807539-04-3

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

Fluorescein-PEG3-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

581.64

Formula

C₂₉H₃₁N₃O₈S

CAS No.

1807539-04-3

SMILES

S=C(NC1=CC2=C(C3(C4=C(OC5=C3C=CC(O)=C5)C=C(O)C=C4)OC2=O)C=C1)NCCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (171.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7193 mL	8.5964 mL	17.1928 mL
5 mM	0.3439 mL	1.7193 mL	3.4386 mL
10 mM	0.1719 mL	0.8596 mL	1.7193 mL

View the Complete Stock Solution Preparation Table

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7193 mL	8.5964 mL	17.1928 mL	42.9819 mL
	5 mM	0.3439 mL	1.7193 mL	3.4386 mL	8.5964 mL
	10 mM	0.1719 mL	0.8596 mL	1.7193 mL	4.2982 mL
	15 mM	0.1146 mL	0.5731 mL	1.1462 mL	2.8655 mL
	20 mM	0.0860 mL	0.4298 mL	0.8596 mL	2.1491 mL
	25 mM	0.0688 mL	0.3439 mL	0.6877 mL	1.7193 mL
	30 mM	0.0573 mL	0.2865 mL	0.5731 mL	1.4327 mL
	40 mM	0.0430 mL	0.2149 mL	0.4298 mL	1.0745 mL
	50 mM	0.0344 mL	0.1719 mL	0.3439 mL	0.8596 mL
	60 mM	0.0287 mL	0.1433 mL	0.2865 mL	0.7164 mL
	80 mM	0.0215 mL	0.1075 mL	0.2149 mL	0.5373 mL
	100 mM	0.0172 mL	0.0860 mL	0.1719 mL	0.4298 mL