1. PROTAC
  2. PROTAC Linkers
  3. TCO4-PEG7-Maleimide

TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

For research use only. We do not sell to patients.

TCO4-PEG7-Maleimide

TCO4-PEG7-Maleimide Chemical Structure

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

View All PROTAC Linkers Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • Customer Review

Description

TCO4-PEG7-Maleimide is a PROTAC linker and belongs to the PEG class. TCO4-PEG7-Maleimide contains TCO and Maleimide groups, which can undergo specific "click" reactions with tetrazine groups or thiol groups, or "mercapto-acrylamide" reactions.

Molecular Weight

671.78

Formula

C32H53N3O12

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCNC(OC1CC/C=C/CCC1)=O)CCN2C(C=CC2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (74.43 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4886 mL 7.4429 mL 14.8858 mL
5 mM 0.2977 mL 1.4886 mL 2.9772 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4886 mL 7.4429 mL 14.8858 mL 37.2146 mL
5 mM 0.2977 mL 1.4886 mL 2.9772 mL 7.4429 mL
10 mM 0.1489 mL 0.7443 mL 1.4886 mL 3.7215 mL
15 mM 0.0992 mL 0.4962 mL 0.9924 mL 2.4810 mL
20 mM 0.0744 mL 0.3721 mL 0.7443 mL 1.8607 mL
25 mM 0.0595 mL 0.2977 mL 0.5954 mL 1.4886 mL
30 mM 0.0496 mL 0.2481 mL 0.4962 mL 1.2405 mL
40 mM 0.0372 mL 0.1861 mL 0.3721 mL 0.9304 mL
50 mM 0.0298 mL 0.1489 mL 0.2977 mL 0.7443 mL
60 mM 0.0248 mL 0.1240 mL 0.2481 mL 0.6202 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

TCO4-PEG7-Maleimide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
TCO4-PEG7-Maleimide
Cat. No.:
HY-156392
Quantity:
MCE Japan Authorized Agent: