Amino-PEG3-C2-sulfonic acid

Name: Amino-PEG3-C2-sulfonic acid
Brand: MedChemExpress
SKU: HY-140001
Rating: 4.5 (1 reviews)

Cat. No.: HY-140001 Purity: 99.47%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Amino-PEG3-C2-sulfonic acid Chemical Structure

CAS No. : 1817735-43-5

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target^[1]

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

257.30

Formula

C₈H₁₉NO₆S

CAS No.

1817735-43-5

Appearance

Oil

Color

Colorless to light yellow

SMILES

NCCOCCOCCOCCS(=O)(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (388.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8865 mL	19.4326 mL	38.8651 mL
5 mM	0.7773 mL	3.8865 mL	7.7730 mL
10 mM	0.3887 mL	1.9433 mL	3.8865 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.47%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (242 KB) HNMR (248 KB) RP-HPLC (239 KB) MS (83 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8865 mL	19.4326 mL	38.8651 mL	97.1628 mL
	5 mM	0.7773 mL	3.8865 mL	7.7730 mL	19.4326 mL
	10 mM	0.3887 mL	1.9433 mL	3.8865 mL	9.7163 mL
	15 mM	0.2591 mL	1.2955 mL	2.5910 mL	6.4775 mL
	20 mM	0.1943 mL	0.9716 mL	1.9433 mL	4.8581 mL
	25 mM	0.1555 mL	0.7773 mL	1.5546 mL	3.8865 mL
	30 mM	0.1296 mL	0.6478 mL	1.2955 mL	3.2388 mL
	40 mM	0.0972 mL	0.4858 mL	0.9716 mL	2.4291 mL
	50 mM	0.0777 mL	0.3887 mL	0.7773 mL	1.9433 mL
	60 mM	0.0648 mL	0.3239 mL	0.6478 mL	1.6194 mL
	80 mM	0.0486 mL	0.2429 mL	0.4858 mL	1.2145 mL
	100 mM	0.0389 mL	0.1943 mL	0.3887 mL	0.9716 mL