Fmoc-NH-PEG6-CH2COOH

Name: Fmoc-NH-PEG6-CH2COOH
Brand: MedChemExpress
SKU: HY-130364
Rating: 4.5 (1 reviews)

Cat. No.: HY-130364 Purity: ≥98.0%: Data Sheet
SDS

COA
Handling Instructions
FAQs
Technical Support

Fmoc-NH-PEG6-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG6-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-NH-PEG6-CH2COOH Chemical Structure

CAS No. : 437655-96-4

Size	Stock	Quantity
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
250 mg	In-stock	Estimated Time of Arrival: December 31
500 mg	Get quote
1 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Small Molecules:

•Related Proteins:

View All ADC Linker Isoform Specific Products:

View All Isoforms

Cleavable Linker Non-cleavable Linker Acid Cleavable Linker Disulfide Cleavable Linker Protease Cleavable Linker Glycosidase Cleavable Linker Phosphatase Cleavable Linker

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]

Cleavable Linker

Alkyl/ether

PEGs

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

561.62

Formula

C₂₉H₃₉NO₁₀

CAS No.

437655-96-4

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)NCCOCCOCCOCCOCCOCCOCC(O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (178.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7806 mL	8.9028 mL	17.8056 mL
5 mM	0.3561 mL	1.7806 mL	3.5611 mL
10 mM	0.1781 mL	0.8903 mL	1.7806 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.15%

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Data Sheet (267 KB) SDS (393 KB)

COA (241 KB) HNMR (122 KB) RP-HPLC (240 KB)

Handling Instructions (2659 KB)

References

[1]. Michael A, et al. Synthesis of Bifunctional Integrin‐Binding Peptides Containing PEG Spacers of Defined Length for Non‐Viral Gene Delivery. Volume2008, Issue17.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7806 mL	8.9028 mL	17.8056 mL	44.5141 mL
	5 mM	0.3561 mL	1.7806 mL	3.5611 mL	8.9028 mL
	10 mM	0.1781 mL	0.8903 mL	1.7806 mL	4.4514 mL
	15 mM	0.1187 mL	0.5935 mL	1.1870 mL	2.9676 mL
	20 mM	0.0890 mL	0.4451 mL	0.8903 mL	2.2257 mL
	25 mM	0.0712 mL	0.3561 mL	0.7122 mL	1.7806 mL
	30 mM	0.0594 mL	0.2968 mL	0.5935 mL	1.4838 mL
	40 mM	0.0445 mL	0.2226 mL	0.4451 mL	1.1129 mL
	50 mM	0.0356 mL	0.1781 mL	0.3561 mL	0.8903 mL
	60 mM	0.0297 mL	0.1484 mL	0.2968 mL	0.7419 mL
	80 mM	0.0223 mL	0.1113 mL	0.2226 mL	0.5564 mL
	100 mM	0.0178 mL	0.0890 mL	0.1781 mL	0.4451 mL