2. Antibody-drug Conjugate/ADC Related PROTAC
  3. ADC Linker PROTAC Linkers
  4. Maleimido-tri(ethylene glycol)-propionic acid

Maleimido-tri(ethylene glycol)-propionic acid  (Synonyms: Mal-PEG3-acid)

Cat. No.: HY-130426 Purity: ≥98.0%
COA
SDS
Handling Instructions Technical Support

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Maleimido-tri(ethylene glycol)-propionic acid

Maleimido-tri(ethylene glycol)-propionic acid Chemical Structure

CAS No. : 518044-40-1

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Based on 1 publication(s) in Google Scholar

Maleimido-tri(ethylene glycol)-propionic acid Related Antibodies

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Description

Maleimido-tri(ethylene glycol)-propionic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Maleimido-tri(ethylene glycol)-propionic acid is used for the preparation of neolymphostin-based ADC precursors for site-specific cysteine mutant trastuzumab-A114C conjugation[1]. Maleimido-tri(ethylene glycol)-propionic acid also can be used as a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

IC50 & Target[1]

Cleavable Linker

 

PEGs

 

In Vitro

Mal-PEG3-C2-acid can be used to synthesis linker-payload 16 (compound 15) and 20 (compound 18). linker-payload 16 amd 20 is conjugated to DAR1.9 and DAR1.7[1].
ADC 23 and 24 are Neolymphostin ADCs that composes of DAG 1.9 and DAG1.7 linked to PIKK inhibitors with linker-payload 16 and 20, respectively[1].
ADC24 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 195 and 202 nM, respectively[1].
ADC23 demonstrates cytotoxic activity against BT474 and N87 cell lines with IC50 of 286 and 274 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Maleimido-tri(ethylene glycol)-propionic acid Related Antibodies
Molecular Weight

301.29

Formula

C13H19NO7
CAS No.
Appearance

Liquid (Density: 1.293±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCOCCN1C(C=CC1=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (244 KB) HNMR (116 KB) MS (147 KB)

Handling Instructions (2659 KB)
References
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Maleimido-tri(ethylene glycol)-propionic acid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Maleimido-tri(ethylene glycol)-propionic acid518044-40-1Mal-PEG3-acidADC LinkerPROTAC LinkersAntibody-drug conjugates linkertrastuzumabADCneolymphostinlinkeranti-tumorInhibitorinhibitorinhibit

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