DBCO-PEG4-PFP ester

Name: DBCO-PEG4-PFP ester
Brand: MedChemExpress
SKU: HY-140278
Rating: 4.5 (1 reviews)

Cat. No.: HY-140278 Purity: ≥95.0%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

DBCO-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

For research use only. We do not sell to patients.

DBCO-PEG4-PFP ester Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All PROTAC Linkers Isoform Specific Products:

View All Isoforms

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
Customer Review

Description

DBCO-PEG4-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. DBCO-PEG4-PFP ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target

PEGs	Alkyl/ether

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

718.66

Formula

C₃₆H₃₅F₅N₂O₈

Appearance

Oil

Color

Colorless to light yellow

SMILES

O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCC(NCCOCCOCCOCCOCCC(OC4=C(C(F)=C(C(F)=C4F)F)F)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (139.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.3915 mL	6.9574 mL	13.9148 mL
5 mM	0.2783 mL	1.3915 mL	2.7830 mL
10 mM	0.1391 mL	0.6957 mL	1.3915 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (268 KB) SDS (393 KB)

COA (242 KB) HNMR (153 KB) RP-HPLC (222 KB) LCMS (100 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.3915 mL	6.9574 mL	13.9148 mL	34.7870 mL
	5 mM	0.2783 mL	1.3915 mL	2.7830 mL	6.9574 mL
	10 mM	0.1391 mL	0.6957 mL	1.3915 mL	3.4787 mL
	15 mM	0.0928 mL	0.4638 mL	0.9277 mL	2.3191 mL
	20 mM	0.0696 mL	0.3479 mL	0.6957 mL	1.7393 mL
	25 mM	0.0557 mL	0.2783 mL	0.5566 mL	1.3915 mL
	30 mM	0.0464 mL	0.2319 mL	0.4638 mL	1.1596 mL
	40 mM	0.0348 mL	0.1739 mL	0.3479 mL	0.8697 mL
	50 mM	0.0278 mL	0.1391 mL	0.2783 mL	0.6957 mL
	60 mM	0.0232 mL	0.1160 mL	0.2319 mL	0.5798 mL
	80 mM	0.0174 mL	0.0870 mL	0.1739 mL	0.4348 mL
	100 mM	0.0139 mL	0.0696 mL	0.1391 mL	0.3479 mL