2. PROTAC
  3. Ligands for E3 Ligase
  4. 3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione 

Cat. No.: HY-W243404 Purity: 99.85%
COA
SDS
Handling Instructions Technical Support

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that can be useful in PROTAC research.

For research use only. We do not sell to patients.

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Structure

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Chemical Structure

CAS No. : 2304513-76-4

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3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Related Antibodies

Top Publications Citing Use of Products

View All Ligands for E3 Ligase Isoform Specific Products:

View All Isoforms
von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

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Description

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione is a Lenalidomide analog that can be useful in PROTAC research.

Molecular Weight

323.15

Formula

C13H11BrN2O3
CAS No.
Appearance

Solid

Color

Gray to gray purple

SMILES

O=C(C(N(CC1=C2C=C(Br)C=C1)C2=O)CC3)NC3=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 13.33 mg/mL (41.25 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0946 mL 15.4729 mL 30.9458 mL
5 mM 0.6189 mL 3.0946 mL 6.1892 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (248 KB) HNMR (116 KB) LCMS (249 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0946 mL 15.4729 mL 30.9458 mL 77.3644 mL
5 mM 0.6189 mL 3.0946 mL 6.1892 mL 15.4729 mL
10 mM 0.3095 mL 1.5473 mL 3.0946 mL 7.7364 mL
15 mM 0.2063 mL 1.0315 mL 2.0631 mL 5.1576 mL
20 mM 0.1547 mL 0.7736 mL 1.5473 mL 3.8682 mL
25 mM 0.1238 mL 0.6189 mL 1.2378 mL 3.0946 mL
30 mM 0.1032 mL 0.5158 mL 1.0315 mL 2.5788 mL
40 mM 0.0774 mL 0.3868 mL 0.7736 mL 1.9341 mL
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3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-(6-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione2304513-76-4Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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