2. PROTAC
  3. PROTAC Linkers
  4. Thiol-PEG2-acid

Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Thiol-PEG2-acid Chemical Structure

Thiol-PEG2-acid Chemical Structure

CAS No. : 1379649-73-6

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Based on 1 publication(s) in Google Scholar

Thiol-PEG2-acid Related Antibodies

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Description

Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Thiol-PEG2-acid Related Antibodies
Molecular Weight

194.25

Formula

C7H14O4S
CAS No.
Appearance

Liquid (Density: 1.173±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=C(O)CCOCCOCCS
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (514.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1480 mL 25.7400 mL 51.4800 mL
5 mM 1.0296 mL 5.1480 mL 10.2960 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥96.0%

SDS (620 KB)

COA (241 KB) HNMR (233 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.1480 mL 25.7400 mL 51.4801 mL 128.7001 mL
5 mM 1.0296 mL 5.1480 mL 10.2960 mL 25.7400 mL
10 mM 0.5148 mL 2.5740 mL 5.1480 mL 12.8700 mL
15 mM 0.3432 mL 1.7160 mL 3.4320 mL 8.5800 mL
20 mM 0.2574 mL 1.2870 mL 2.5740 mL 6.4350 mL
25 mM 0.2059 mL 1.0296 mL 2.0592 mL 5.1480 mL
30 mM 0.1716 mL 0.8580 mL 1.7160 mL 4.2900 mL
40 mM 0.1287 mL 0.6435 mL 1.2870 mL 3.2175 mL
50 mM 0.1030 mL 0.5148 mL 1.0296 mL 2.5740 mL
60 mM 0.0858 mL 0.4290 mL 0.8580 mL 2.1450 mL
80 mM 0.0644 mL 0.3218 mL 0.6435 mL 1.6088 mL
100 mM 0.0515 mL 0.2574 mL 0.5148 mL 1.2870 mL
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Thiol-PEG2-acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiol-PEG2-acid1379649-73-6PROTAC LinkersInhibitorinhibitorinhibit

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