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1a

" in MedChemExpress (MCE) Product Catalog:

624

Inhibitors & Agonists

1

Fluorescent Dye

4

Biochemical Assay Reagents

29

Peptides

16

Inhibitory Antibodies

21

Natural
Products

516

Recombinant Proteins

12

Isotope-Labeled Compounds

275

Antibodies

2

Click Chemistry

319

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-137584
    1a,1b-Dihomo prostaglandin E1

    1a,1b-Dihomo PGE1

    		 Prostaglandin Receptor Endocrinology
    1a,1b-Dihomo prostaglandin E1 (1a,1b-Dihomo PGE1) is a class of prostaglandin compound [1].
    1a,1b-Dihomo prostaglandin E1
  • HY-104064
    1A-116
    5+ Cited Publications

    		 Ras Apoptosis Cancer
    1A-116, a potent Rac1 inhibitor, is specific for W56 residues, can prevent EGF-induced Rac1 activation and block Rac1-P-Rex1 interaction. 1A-116 can induce apoptosis and inhibit cell proliferation, migration and cycle progression in a concentration-dependent manner. 1A-116 also demonstrates a high antimetastatic activity in vivo [1] .
    1A-116
  • HY-W128112
    1-(a-D-ribofuranosyl)uracil

    alpha-D-Ribofuranoside,2,4(1H,3H)-pyrimidinedione-1

    		 Nucleoside Antimetabolite/Analog Cancer
    1-(a-D-ribofuranosyl)uracil is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc [1].
    1-(a-D-ribofuranosyl)uracil
  • HY-P3915
    Esculentin 1A

    		Bacterial Infection
    Esculentin 1A is a frog skin-derived antimicrobial peptide (AMP) with potent in vitro anti-Pseudomonas activity [1].
    Esculentin 1A
  • HY-131632
    1a,1b-Dihomo prostaglandin F2α

    1a,1b-Dihomo-PGF2α

    		 Endogenous Metabolite Others
    1a,1b-Dihomo prostaglandin F2α (1a,1b-Dihomo-PGF2α) is the derivative of Prostaglandin F2α (HY-12956) [1].
    1a,1b-Dihomo prostaglandin F2α
  • HY-131626
    1a,1b-Dihomo prostaglandin E2

    1a,1b-Dihomo PGE2

    		 COX Metabolic Disease
    1a,1b-Dihomo Prostaglandin E2 (PGE2) is a rare polyunsaturated fatty acid first identified in extracts of sheep vesicular gland microsomes, known to contain COX, incubated with adrenic acid. 1a,1b-Dihomo PGE2 has also been identified in conditioned media of RAW 264.7 macrophages stimulated with endotoxin and arachidonic acid. This product is thought to be produced by elongation of AA to adrenic acid, which is then metabolized sequentially by COX and PGE synthase.
    1a,1b-Dihomo prostaglandin E2
  • HY-159675
    1-A-N

    		Liposome Inflammation/Immunology
    1-A-N is a lipid nanoparticle (LNP) used for in vivo delivery of siRNA. 1-A-N can regulate immune response by delivering siCD45 (siRNA targeting CD45) to T cells and silencing the CD45 gene [1].
    1-A-N
  • HY-N13946
    Pyralomicin 1a

    		Antibiotic Bacterial Infection
    Pyralomicin 1a is an antibiotic with antibacterial activity [1].
    Pyralomicin 1a
  • HY-N14581
    Roselipin 1A

    		Acyltransferase Infection
    Roselipin 1A inhibits diacylglycerol acyltransferases (DGAT) of rat hepatic microcosm [1].
    Roselipin 1A
  • HY-146483
    Anti-Aβ agent 1A

    		Amyloid-β Neurological Disease Inflammation/Immunology
    Anti-Aβ agent 1A (compound M15) has potent activity against amyloid-β. Anti-Aβ agent 1A possesses can significantly inhibit LPS-induced levels of IL-1β, IL-6 and TNF-α, and reduces the apoptosis of SH-SY5Y induced by H2O2 through mitochondria pathway. Anti-Aβ agent 1A possesses antioxidant, anti-inflammatory, anti-Aβ toxicity and neuroprotective activities. Anti-Aβ agent 1A can be used for researching Alzheimer’s disease (AD) [1].
    Anti-Aβ agent 1A
  • HY-134913
    Rhodblock 1a

    		ROCK Cardiovascular Disease Cancer
    Rhodblock 1a is an inhibitor of the Rho kinase signaling pathway. It inhibits the normal formation of the cleavage furrow during cell division by interfering with the localization and function of Rho pathway proteins, causing some cells to fail to form a cleavage furrow or the formed cleavage furrow to break, resulting in binucleated cells. Rhodblock 1a can be used to study the mechanism of cell division and is expected to be used in the research of diseases such as cardiovascular diseases and cancer [1].
    Rhodblock 1a
  • HY-N14785
    Deflectin 1a

    		Antibiotic Bacterial Infection Cancer
    Deflectin 1a is an antibiotic with the activity of lysing bacteria, lysing red blood cells and inhibiting Ehrlich ascites cancer cells, and its activity can be offset by adding serum or serum albumin [1].
    Deflectin 1a
  • HY-50202A
    Etomoxir sodium salt
    Maximum Cited Publications
    107 Publications Verification

    (R)-(+)-Etomoxir sodium salt

    		 Apoptosis Metabolic Disease Cancer
    Etomoxir((R)-(+)-Etomoxir) sodium salt is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1].
    Etomoxir sodium salt
  • HY-108790
    Peginterferon beta-1a

    Peginterferon β-1a

    		 Apoptosis Neurological Disease Cancer
    Peginterferon beta-1a (Peginterferon β-1a) is the first pegylated interferon beta-1a molecule. Peginterferon beta-1a induces cancer cells apoptosis and shows anti-tumor activities in nude mice models. Peginterferon beta-1a can be used for the research of cancer and multiple sclerosis (RMS) [1].
    Peginterferon beta-1a
  • HY-100431AR
    IMR-1A (Standard)

    		Reference Standards Notch Drug Metabolite Cancer
    IMR-1A (Standard) is the analytical standard of IMR-1A. This product is intended for research and analytical applications. IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].
    IMR-1A (Standard)
  • HY-173271
    GHSR-1a agonist-1

    		GHSR Endocrinology
    GHSR-1a agonist-1 (Compound 4b) is an orally active agonist of the human growth hormone secretagogue receptor 1a (GHSR-1a), with an EC50 of 0.49 nM. GHSR-1a agonist-1 can effectively stimulate the release of endogenous growth hormone by activating GHSR-1a. GHSR-1a agonist-1 administered orally at a dose as low as 0.1 mg/kg can increase the body weight and body length of 4-week-old rats. GHSR-1a agonist-1 can be used in the research field of growth and development retardation in children [1].
    GHSR-1a agonist-1
  • HY-100431A
    IMR-1A
    1 Publications Verification

    		 Notch Drug Metabolite Cancer
    IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1].
    IMR-1A
  • HY-P99138
    Anti-Mouse IL-1a Antibody (ALF-161)

    		Interleukin Related Inflammation/Immunology Cancer
    Anti-Mouse IL-1a Antibody (ALF-161) is an anti-mouse IL-1a IgG1 monoclonal antibody. Anti-Mouse IL-1a Antibody (ALF-161) can inhibit CD8 + T cell response by blocking IL-1a signaling. Anti-Mouse IL-1a Antibody (ALF-161) can reversibly transform myeloid cell expansion and improve T cell function. Anti-Mouse IL-1a Antibody (ALF-161) can be used for research on immune response and cancer such as breast cancer [1] .
    Anti-Mouse IL-1a Antibody (ALF-161)
  • HY-100840
    (S)-4C3HPG

    (S)-4-Carboxy-3-hydroxyphenylglycine

    		 mGluR Neurological Disease
    (S)-4C3HPG ((S)-4-Carboxy-3-hydroxyphenylglycine) is an antagonist of metabotropic glutamate receptor 1a (mGluR 1a) and an agonist of GluR2. (S)-4C3HPG has the anticonvulsant activity and protects against audiogenic seizures in DBA/2 mice [1].
    (S)-4C3HPG
  • HY-163121
    PST3.1a

    		Glycosyltransferase Cancer
    PST3.1a is a N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with the IC50 of 2 μM. PST3.1a inhibits glioblastoma-initiating cell invasiveness and proliferation [1].
    PST3.1a
  • HY-136267
    HCV-IN-30

    		HCV Infection
    HCV-IN-30 (compound 48) is a HCV NS5A replication complex inhibitor, with IC50s of 901 and 102 nM for genotypes 1a and 1b replicons, respectively [1].
    HCV-IN-30
  • HY-136972
    (-)-GB-1a

    (-)-Biflavanone GB-1a

    		 Biochemical Assay Reagents Others
    (-)-GB-1a is a potent antioxidant agent with an IC50 value of 148 µM [1].
    (-)-GB-1a
  • HY-136532
    ZT-1a
    3 Publications Verification

    		 NKCC Neurological Disease
    ZT-1a is a potent, non-ATP-competitive and selective SPAK inhibitor. ZT-1a inhibits SPAK activity with IC50s of 44.3, 35.0, 46.7 μM at ATP concentrations of 0.01, 0.1 and 1 mM, respectively [1].
    ZT-1a
  • HY-155383
    TNIR7-1A

    		Tau Protein Neurological Disease Cancer
    TNIR7-1A is a fused cycloheptatriene–BODIPY derivative that displays properties favorable for near-infrared (NIR) imaging (Ex/Em = 600/774 nm in PBS) with high affinity and specificity to Neurofibrillary tangles (NFTs) in vitro. TNIR7-1A effectively penetrated the blood–brain barrier [1].
    TNIR7-1A
  • HY-118335
    Prazobind

    SZL 49

    		 Adrenergic Receptor Cardiovascular Disease
    Prazobind (SZL 49), a prazosin analog, is a selective α1-adrenoceptor antagonist. Prazobind competes for alpha 1-adrenoceptor binding sites with a similar potency (IC50 of 1 nM) in tissues enriched in both the alpha 1A (hippocampus) and alpha 1B (liver) subtypes. Prazobind can be used for the study of blood pressure [1] .
    Prazobind
  • HY-50202
    Etomoxir
    Maximum Cited Publications
    107 Publications Verification

    (R)-(+)-Etomoxir

    		 Apoptosis Metabolic Disease Cancer
    Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir
  • HY-176550
    ASIC1a antagonist-1

    		Sodium Channel Neurological Disease
    ASIC1a antagonist-1 (Compound 5b) is an orthosteric noncompetitive Acid sensing ion channels 1a (ASIC1a) antagonist with an IC50 of 27 nM (pH 6.7). ASIC1a antagonist-1 shifts pH dependence of ASIC1a activation and inhibits its maximal evoked response. ASIC1a antagonist-1 completely inhibits long-term potentiation (LTP) induction in CA3-CA1 pathway. ASIC1a antagonist-1 can be used for brain diseases and pathologies research [1].
    ASIC1a antagonist-1
  • HY-W420033
    (S)-(+)-Etomoxir

    		Acyltransferase Others
    (S)-(+)-Etomoxir is the S enantiomer of Etomoxir (HY-50202). Etomoxir is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig [1].
    (S)-(+)-Etomoxir
  • HY-50202R
    Etomoxir (Standard)

    		Apoptosis Metabolic Disease Cancer
    Etomoxir (Standard) is the analytical standard of Etomoxir. This product is intended for research and analytical applications. Etomoxir ((R)-(+)-Etomoxir) is an irreversible inhibitor of carnitine palmitoyltransferase 1a (CPT-1a), inhibits fatty acid oxidation (FAO) through CPT-1a and inhibits palmitate β-oxidation in human, rat and guinea pig.
    Etomoxir (Standard)
  • HY-131994
    STING agonist-16

    		STING Infection Cancer
    STING agonist-16 (1a) is a specific stimulator of interferon genes (STING) agonist. STING agonist-16 (1a) can be used as a potential antiviral and antitumor tool [1].
    STING agonist-16
  • HY-R02807
    mmu-miR-1a-2-5p mimic

    		MicroRNA Cancer
    mmu-miR-1a-2-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1a-2-5p mimic
    mmu-miR-1a-2-5p mimic
  • HY-R02806
    mmu-miR-1a-1-5p mimic

    		MicroRNA Cancer
    mmu-miR-1a-1-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.
    mmu-miR-1a-1-5p mimic
    mmu-miR-1a-1-5p mimic
  • HY-169174
    Antifungal agent 116

    		Fungal Cancer
    Antifungal agent 116 (compund 1a) has broad-spectrum antifungal activity [1].
    Antifungal agent 116
  • HY-B1304
    (-)-Sparteine sulfate pentahydrate

    (-)-Lupinidine sulfate pentahydrate

    		 Sodium Channel Cardiovascular Disease
    (-)-Sparteine sulfate pentahydrate ((-)-Lupinidine sulfate pentahydrate) is a class 1a antiarrhythmic agent and a sodium channel blocker.
    (-)-Sparteine sulfate pentahydrate
  • HY-168265
    Dyrk1A-IN-11

    		DYRK Neurological Disease Cancer
    Dyrk1A-IN-11 (compound 166) is a potent dual-specificity tyrosine phosphorylation- regulated 1A (DYRK1A) inhibitor with an EC50 value of 0.0021 µM. Dyrk1A-IN-11 inhibits the Phospho-Tau (Thr212) with an EC50 value of 0.0361 µM [1].
    Dyrk1A-IN-11
  • HY-115608
    cis-4P-PDOT

    		Biochemical Assay Reagents Others
    cis-4P-PDOT (compound 1a) is a 8-methoxy analog [1].
    cis-4P-PDOT
  • HY-15522
    WAY-267464

    		Oxytocin Receptor Neurological Disease
    WAY-267464 is a non-peptide oxytocin receptor (OTR) agonist. WAY-267464 can impair social recognition memory in rats through a vasopressin 1A receptor antagonist action. WAY-267464 can be used for the research of psychiatric disorders, such disorders include autism spectrum disorder, schizophrenia, and social anxiety disorder [1].
    WAY-267464
  • HY-164220
    PPM1A-IN-1

    		Phosphatase Bacterial Infection
    PPM1A-IN-1 (Compound IV-4) is an inhibitor for PP2C Ser/Thr phosphatase protein phosphatase Mg2+/Mn2+-dependent 1A. PPM1A-IN-1 exhibits antibacterial activity against Mycobacterium tuberculosis [1].
    PPM1A-IN-1
  • HY-100426
    Osemozotan

    MKC242 free base

    		 5-HT Receptor Others
    Osemozotan (MKC242 free base) acts as an agonist for the 5-HT(1A) receptor.
    Osemozotan
  • HY-157448
    CBR1-IN-6

    		Apoptosis Cancer
    CBR1-IN-6 (compound 1a) is a CBR1 inhibitor with chemosensitizing and cardioprotective activities [1].
    CBR1-IN-6
  • HY-12294
    PEAQX

    NVP-AAM077

    		 Caspase Apoptosis iGluR Neurological Disease
    PEAQX (NVP-AAM077) is an orally active and selective NMDA antagonist, with IC50 values of 270 nM and 29.6 μM for hNMDAR 1A/2A and hNMDAR 1A/2B, respectively. PEAQX can promote the activation of caspase-3 and induce cell apoptosis in cortical striatal slice cultures [1] .
    PEAQX
  • HY-U00433
    JMV 2959
    3 Publications Verification

    		 GHSR Neurological Disease Endocrinology
    JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.
    JMV 2959
  • HY-161978
    CDK4/6-IN-22

    		CDK Cancer
    CDK4/6-IN-22 (Compound 1-A) is a CDK4 and CDK6 dual inhibitor [1].
    CDK4/6-IN-22
  • HY-RI02806
    mmu-miR-1a-1-5p inhibitor

    		MicroRNA Cancer
    mmu-miR-1a-1-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1a-1-5p inhibitor
    mmu-miR-1a-1-5p inhibitor
  • HY-RI02807
    mmu-miR-1a-2-5p inhibitor

    		MicroRNA Cancer
    mmu-miR-1a-2-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.
    mmu-miR-1a-2-5p inhibitor
    mmu-miR-1a-2-5p inhibitor
  • HY-129314
    CM-39

    		Aldehyde Dehydrogenase (ALDH) Cancer
    CM-39 is a non-covalent and reversible inhibitor for aldehyde dehydrogenase 1A (ALDH1A) with an IC50 of 0.9 μM [1].
    CM-39
  • HY-149694
    Aurora kinase inhibitor-12

    		Aurora Kinase Cancer
    Aurora kinase inhibitor-12 (Compound 1a ) is the inhibitor of aurora kinase which is a key enzyme that is implicated in tumor growth [1].
    Aurora kinase inhibitor-12
  • HY-12782T
    Iadademstat dihydrochloride
    5 Publications Verification

    ORY-1001 dihydrochloride; RG6016 dihydrochloride; RO 7051790 dihydrochloride

    		 Histone Demethylase Cancer
    Iadademstat (ORY-1001) dihydrochloride is a selective irreversible lysine (K)-specific demethylase 1A (KDM1A/LSD1) inhibitor.
    Iadademstat dihydrochloride
  • HY-115938
    BEC2

    		Acyltransferase Metabolic Disease Cancer
    BEC2 is an ester derivative of Baicalin, with good lipid-lowering activity. BEC2 can direct activate the carnitine palmitoyltransferase 1A (CPT1A) [1].
    BEC2
  • HY-W006672
    Dibenzo[b,e]oxepin-11(6H)-one

    		Parasite Infection
    Dibenzo[b,e]oxepin-11(6H)-one (Compound 1a) is a dibenzoxepinone derivative that exhibits significant antiparasitic activity [1].
    Dibenzo[b,e]oxepin-11(6H)-one

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