MOB1 Antibody (YA6006)

MOB1 Antibody (YA6006) is a rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MOB1. It can be applicated for WB, ICC/IF, IP, ELISA assays, in the background of human, mouse, rat.

MOB1 is an activator of LATS1/2 in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway consists of a kinase cascade where STK3/MST2 and STK4/MST1, in complex with their regulatory protein SAV1, phosphorylate and activate LATS1/2 in complex with its regulatory protein MOB1. This, in turn, phosphorylates and inactivates the oncoproteins YAP1 and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its nuclear translocation, thereby regulating cellular genes critical for cell proliferation, cell death, and cell migration. MOB1 also stimulates the kinase activity of STK38 and STK38L and cooperates with STK3/MST2 to activate STK38.

Q9H8S9

Predicted band size: 24 kDa; Observed band size: 24 kDa

Protein A

Non-conjugated

Unmodified

Primary Antibody; Recombinant Rabbit Monoclonal Antibody

Monoclonal

Rabbit

Human, Mouse, Rat

WB: 1:2000-1:10000; ICC/IF: 1:200-1:1000; ELISA: 1:5000-1:20000; IP: 1:50-1:200;

WB, ICC/IF, IP, ELISA

Liquid

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping with blue ice.

IgG