Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)

Cat. No.: HY-P990221 Purity: ≥95.0%: Data Sheet
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Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse IL-17F. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can neutralize IL-17. Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) can be used for the researches of cancer, infection and neurological disease, such as Alzheimer’s disease (AD) and pancreatic cancer.

For research use only. We do not sell to patients.

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Chemical Structure

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Featured Recommendations:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

Biological Activity
Purity & Documentation
References
Customer Review

Description

Isotype

Mouse IgG1 kappa

Recommend Isotype Controls

Mouse IgG1 kappa, Isotype Control

Species Reactivity

Mouse

IC₅₀ & Target

IL-17F

In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (200 μg for the first day and 100 μg every other day thereafter, i.p., 3 weeks) restores neurodegenerative microglia response and cognition in Alzheimer’s disease mice ^[1].
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (400 μg, i.p., every 3-4 days until 6 weeks) reduces disease burden and pathological fibrosis in pancreatic cancer mice models^[2].
Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) (200 μg at days −1 and 100 μg every other day thereafter, i.p.) shows anti-infection effect companied with anti-IL-17A (HY-P990222) in S. aureus infected mice models^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Alzheimer’s disease mice models^[1]
Dosage:	200 μg for the first day and 100 μg every other day
Administration:	Intraperitoneally injection, 3 weeks
Result:	Reduced neutrophil recruitment and proportion of γδ T cells. Increased proportion of phagocytic microglia. Reduced IL-17, IL-8 and TGFβ signaling in non-phagocytic microglia and neutrophil degranulation in phagocytic microglia. Reduced accumulation of neutrophils at the choroid plexus. Increased immunoreactivity of Clec7a+ neurodegenerative microglia.

Animal Model:	S. aureus infected mice models^[3]
Dosage:	200 μg at days −1 and 100 μg every other day thereafter
Administration:	Intraperitoneally injection, companied with anti-IL-17A (HY-P990222)
Result:	Resulted in statistically increased lesion sizes and in vivo BLI signals.

Gene ID

257630 [NCBI]

Accession

Q7TNI7-1

Application

ELISA, FACS, Functional assay, Research in vivo

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (263 KB) SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)

References

[1]. Rosenzweig N, et al. Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease. Nat Med. 2024 Oct;30(10):2990-3003. [Content Brief]

[2]. Hegde S, et al. Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer. Cancer Cell. 2020 Mar 16;37(3):289-307.e9. [Content Brief]

[3]. Marchitto MC, et al. Clonal Vγ6+Vδ4+ T cells promote IL-17-mediated immunity against Staphylococcus aureus skin infection. Proc Natl Acad Sci U S A. 2019 May 28;116(22):10917-10926. [Content Brief]

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-17F Antibody (MM17F8F5.1A9)Interleukin RelatedILIL-17Alzheimer’s diseasePancreatic cancerS. aureusMicrogliaInhibitorinhibitorinhibit

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