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  4. Monoclonal Antibodies Recombinant Antibodies
  5. Activin Receptor Type IA Antibody (YA1994)

Activin Receptor Type IA Antibody (YA1994)

Cat. No.: HY-P82249
COA
SDS
User Guide for Antibodies Technical Support

Activin Receptor Type IA Antibody (YA1994) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1994), targeting Activin Receptor Type IA, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). Activin Receptor Type IA Antibody (YA1994) can be used for WB, IP experiment in human, mouse background.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products

【WB: Western Blot; IHC-P: Immunohistochemistry-Paraffin; IHC-F: Immunohistochemistry-Frozen; ICC/IF: Immunocytochemistry/Immunofluorescence; IF-Tissue: Immunofluorescence-Tissue; mIHC: Multiplex Immunohistochemical; IP: Immunoprecipitation; ChIP: Chromatin Immunoprecipitation; FC: Flow Cytometry; ELISA: Enzyme Linked Immunosorbent Assay】

  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

Activin Receptor Type IA Antibody (YA1994) is a rabbit-derived non-conjugated IgG antibody (Clone NO.: YA1994), targeting Activin Receptor Type IA, with a predicted molecular weight of 57 kDa (observed band size: 57 kDa). Activin Receptor Type IA Antibody (YA1994) can be used for WB, IP experiment in human, mouse background.
Background

Activin Receptor Type IA (ACVR1) is a bone morphogenetic protein (BMP) type I receptor involved in diverse biological processes including bone, heart, cartilage, nervous system and reproductive system development. Forming heterotetrameric complexes with type II receptors (AMHR2, ACVR2A or ACVR2B), it becomes transphosphorylated upon ligand (e.g., BMP7 or GDF2/BMP9) binding, subsequently phosphorylating SMAD1/5/8 to mediate BMP signaling (by similar: may activate non-canonical p38 MAPK pathways). ACVR1 also suppresses TGFβ/activin pathway signaling by competitively inhibiting activin binding to type II receptors (by similar: potentially promotes HAMP expression through BMP6 interaction).
Gene ID
SwissProt ID
Synonyms
ACTRI; Acvr1; ACVR1A; ACVRLK2; ALK2; FOP; SKR1; TSRI
Molecular Weight

Predicted band size: 57 kDa; Observed band size: 57 kDa
Purity

Affinity Purified
Conjugation

Non-conjugated
Modification

Unmodified
Research Field

Signal Transduction
Product Categories

Primary Antibody; Recombinant Rabbit Monoclonal Antibody
Clonality

Recombinant, Monoclonal
Host

Rabbit
Reactivity

Human, Mouse
Dilution Ratio

WB: 1/500-1/1000;IP: 1/20
Application

WB, IP
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Isotype

IgG
Sensitivity

Endogenous
Immunogen

A synthetic peptide of human Activin Receptor Type IA
Database

Entrez Gene: 90 Human ; 11477 Mouse ; 79558 Rat

SwissProt: Q04771 Human ; P37172 Mouse ; P80201 Rat

OMIM: 135100 Human

Documentation
SDS (251 KB)

COA (191 KB)

User Guide for Antibodies (1077 KB)

Activin Receptor Type IA Antibody (YA1994) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Activin Receptor Type IA Antibody (YA1994)
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