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  4. BMPR1A/ALK-3 Protein, Human (HEK293, hFc)

BMPR1A/ALK-3 Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR1A/ALK-3 protein, expressed by HEK293, with C-hFc tag.

For research use only. We do not sell to patients.

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Description

BMPR1A/ALK-3 Protein, Human (HEK293, hFc) is the recombinant human-derived BMPR1A/ALK-3 protein, expressed by HEK293, with C-hFc tag.
Background

BMPR1A is a transmembrane serine/threonine kinase that forms a receptor complex consisting of two type II and two type I receptors upon ligand binding. Type II receptors phosphorylate and activate type I receptors, which autophosphorylate and subsequently bind and activate SMAD transcriptional regulators. It serves as a receptor for BMP2, BMP4, GDF5, and GDF6, positively regulating chondrocyte differentiation through GDF5 interaction and mediating adipogenesis induction by GDF6. Additionally, it may promote HAMP expression, potentially via its interaction with BMP2 (By similarity).
Species

Human
Source

HEK293
Tag

C-hFc
Accession

P36894 (Q24-R152)
Gene ID

657
Protein Length

Extracellular Domain
Synonyms
ALK-3; BMPR­IA; Bone morphogenetic protein receptor type-1A; SKR5; CD292
Predicted Molecular Mass
40.9 kDa
Glycosylation
Yes
Purity

Greater than 95% as determined by reducing SDS-PAGE..
Endotoxin Level

<1 EU/μg, determined by LAL method.
Documentation
Handling Instructions (2659 KB)

BMPR1A/ALK-3 Protein, Human (HEK293, hFc) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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BMPR1A/ALK-3 Protein, Human (HEK293, hFc)
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